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danaSeq

Docs License: MIT

Metagenomic analysis pipelines and data visualization dashboards for Oxford Nanopore and Illumina sequencing data. Four Nextflow DSL2 pipelines cover real-time read processing, long-read assembly, short-read assembly, and downstream MAG analysis.

Full documentation

Pipelines

Pipeline Purpose Key tools
nanopore_live Real-time analysis during sequencing Kraken2, Prokka/Bakta, HMMER3, DuckDB
nanopore_assembly Long-read assembly + mapping + depth Flye, metaMDBG, myloasm, minimap2, CoverM
illumina_assembly Multi-assembler consensus assembly Tadpole, Megahit, SPAdes, metaSPAdes, BBMap
mag_analysis Downstream MAG analysis 7-binner consensus, DAS Tool, Binette, 50+ processes

Quick Start

git clone https://github.com/rec3141/danaSeq.git
cd danaSeq

# Real-time processing
cd nanopore_live
./install.sh && ./install.sh --check
./run-realtime.sh --input /path/to/nanopore/run --outdir /path/to/output \
    --run_kraken --kraken_db /path/to/krakendb \
    --run_prokka --run_sketch --run_tetra

# MAG analysis
cd ../mag_analysis
./install.sh && ./install.sh --check
./run-mag-analysis.sh \
    --assembly /path/to/assembly.fasta \
    --depths /path/to/depths.txt \
    --outdir /path/to/output \
    --db_dir /path/to/databases --all

Databases

./download-databases.sh              # Interactive menu
./download-databases.sh --human      # Human reference (~4 GB)
./download-databases.sh --genomad --checkv --checkm2 --kaiju

License

MIT. See LICENSE.

Repository: https://github.com/rec3141/danaSeq Documentation: https://rec3141.github.io/danaSeq/

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Analysis Pipeline and Dashboard for Environmental Metagenomics

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