Contributor submission AscG

mite_data/data/MITE9999999.json

@@ -0,0 +1,70 @@
+{
+    "accession": "MITE9999999",
+    "status": "active",
+    "changelog": [
+        {
+            "version": "1",
+            "date": "2026-05-16",
+            "contributors": [
+                "0000-0002-0771-9611"
+            ],
+            "reviewers": [
+                "0000-0001-6534-6609"
+            ],
+            "comment": "New entry. Reviewer 1 improved reaction description, added cofactors and rhea ID + EC number."
+        }
+    ],
+    "enzyme": {
+        "name": "AscG",
+        "description": "Cytochrome P450",
+        "references": [
+            "doi:10.1073/pnas.1819254116"
+        ],
+        "databaseIds": {
+            "uniprot": "A0A455R4X0",
+            "genpept": "BBF25319.1",
+            "mibig": "BGC0001923"
+        },
+        "cofactors": {
+            "organic": [
+                "Heme",
+                "NADP"
+            ],
+            "inorganic": [
+                "Fe"
+            ]
+        }
+    },
+    "reactions": [
+        {
+            "tailoring": [
+                "Oxidation"
+            ],
+            "description": "Oxidation of meroterpenoid precursor in the ascochlorin biosynthetic pathway, resulting in mature ascochlorin.",
+            "reactionSMARTS": "[#6](-[#6]-[#6]-[#6@@]1(\\[#6])-[#6@](\\[#6])-[#6]-[#6]-[#6](=[#8])-[#6@@]-1\\[#6])(=[#6]-[#6]-[#6]1:[#6](-[#8]):[#6](-[#6]=[#8]):[#6](-[#6]):[#6](-[Cl]):[#6]:1-[#8])-[#6]>>[#6](-[#6]=[#6]-[#6@@]1(\\[#6])-[#6@](\\[#6])-[#6]-[#6]-[#6](=[#8])-[#6@@]-1\\[#6])(=[#6]-[#6]-[#6]1:[#6](-[#8]):[#6](-[#6]=[#8]):[#6](-[#6]):[#6](-[Cl]):[#6]:1-[#8])-[#6]",
+            "reactions": [
+                {
+                    "substrate": "C/C(=C\\Cc1c(O)c(Cl)c(C)c(C=O)c1O)CC[C@@]1(C)[C@H](C)CCC(=O)[C@@H]1C",
+                    "products": [
+                        "CC(C=C[C@@]1(C)[C@H](C)CCC(=O)[C@@H]1C)=CCc1c(O)c(Cl)c(C)c(C=O)c1O"
+                    ],
+                    "isIntermediate": false,
+                    "description": "Conversion of alicicolin C to ascochlorin."
+                }
+            ],
+            "evidence": {
+                "evidenceCode": [
+                    "In vitro assay",
+                    "Knock-out studies"
+                ],
+                "references": [
+                    "doi:10.1073/pnas.1819254116"
+                ]
+            },
+            "databaseIds": {
+                "rhea": "63100",
+                "ec": "1.14.14"
+            }
+        }
+    ]
+}