Analysis scripts for "Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning"

1. PCA analysis: joint_pca_full.R
2. Clinical associations of PCs: pc_sex_differences.R
3. GWAS: Code_GWAs.pdf
4. Mediation tests (Structural Equation Models): mediation.R
5. Local heritability and genetic correlation: local_h2_rg.R
6. TWAS fine-mapping: fine_mapping_pc5_and_related.sh

Reference: https://doi.org/10.1101/2022.08.02.22278185