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feat: pilot-panel — 20-candidate first-synthesis-wave selector - #14
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…ector Selects a first-synthesis-wave panel of 20 from the 89 nominated AMP candidates by maximising ensemble score and minimising scorer disagreement (priority = ensemble - 0.3 * disagreement), guaranteeing at least one representative per seed template. - src/openamp_foundry/selection/pilot.py: selection algorithm - src/openamp_foundry/reports/pilot_panel.py: CSV + markdown output - cli.py: 'pilot-panel' subcommand - Makefile: 'make pilot' target (depends on phase3) - tests/test_pilot_panel.py: 27 tests (341 total passing)
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Summary
make pilotruns the full pipeline and selects 20 candidates for first-wave synthesis from the 89 nomineessrc/openamp_foundry/selection/pilot.py): priority =ensemble − 0.3 × disagreement; guarantees ≥1 candidate per seed template, fills remaining slots by priority ranksrc/openamp_foundry/reports/pilot_panel.py): synthesis-ready CSV (outputs/pilot_panel.csv) and human-readable markdown (outputs/pilot_panel.md) with disclaimer, next-steps checklist, reproducibility blockopenamp-foundry pilot-panel --ranked <jsonl> --n 20 --out-csv <csv> [--out-md <md>]Why 20
Cost-effective for a first assay wave (~$5–12k synthesis + MIC/hemolysis/stability). At 30% in-vitro hit rate, 20 candidates gives ~6 hits — enough signal to direct the second wave. All 5 seed families are represented so no sequence space is abandoned before wet-lab data arrives.
Test plan
make test— 341 passedmake pilot— produces 20 candidates across SEED-001..005outputs/pilot_panel.mdbefore ordering synthesis🤖 Generated with Claude Code