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RecB DNA binding article

This repository contains the latex files, data and Python scripts used in the article: Thédié D., Lepore A., McLaren L, El Karoui, M. (2024). (Insert title here) bioRxiv. DOI: (Insert DOI here)

Data storage

The Dataset list table lists all datasets used in this study, with a unique identifier ("Name"), and other basic information (ciprofloxacin concentration, strain used, overexpressed proteins...). Dataset names can be used to find:

  • Raw images on (link to be added)
  • Processed BACMMAN datasets (see the BACMMAN datasets folder)

Steps to reproduce the analysis workflow

  1. Clone this repository to your computer
    • If you do not wish to re-process the images in BACMMAN, skip to step 5.
  2. Download the raw images from (update when available)
  3. Install the BACMMAN Fiji plugin
  4. Open the BACMMAN plugin in Fiji
    • Set the BACMMAN_datasets folder of this repository as working directory
    • Open the dataset of interest (refer to Dataset_list for more details)
    • Re-link the raw images by selecting the matching folder (in BACMMAN, select "Run" then "Import/Re-link images")
    • Run Pre-processing and Processing. Note this will erase any manual curation of cells that had been done by the authors
    • If required, open images in the "Data Browsing" tab and curate objects manually (e.g. remove badly segmented cells)
    • Run Measurements and Extract Measurements
  5. Open a Jupyter Notebook from the Notebooks folder
    • If you have not already, install the PyBerries package and its dependencies
    • Run the cells of the Notebook to generate Figures (the code does not need to be updated)

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