diff --git a/core/trino-main/src/main/java/io/trino/sql/analyzer/StatementAnalyzer.java b/core/trino-main/src/main/java/io/trino/sql/analyzer/StatementAnalyzer.java
index e0321331a4ac..9f6b4aefac1b 100644
--- a/core/trino-main/src/main/java/io/trino/sql/analyzer/StatementAnalyzer.java
+++ b/core/trino-main/src/main/java/io/trino/sql/analyzer/StatementAnalyzer.java
@@ -3270,14 +3270,14 @@ protected Scope visitUpdate(Update update, Optional<Scope> scope)
                     .collect(toImmutableMap(ColumnSchema::getName, Function.identity()));
 
             for (UpdateAssignment assignment : update.getAssignments()) {
-                String columnName = assignment.getName().getValue();
+                String columnName = assignment.getName().getValue().toLowerCase(ENGLISH);
                 if (!columns.containsKey(columnName)) {
                     throw semanticException(COLUMN_NOT_FOUND, assignment.getName(), "The UPDATE SET target column %s doesn't exist", columnName);
                 }
             }
 
             Set<String> assignmentTargets = update.getAssignments().stream()
-                    .map(assignment -> assignment.getName().getValue())
+                    .map(assignment -> assignment.getName().getValue().toLowerCase(ENGLISH))
                     .collect(toImmutableSet());
             accessControl.checkCanUpdateTableColumns(session.toSecurityContext(), tableName, assignmentTargets);
 
@@ -3325,7 +3325,7 @@ protected Scope visitUpdate(Update update, Optional<Scope> scope)
             List<Type> expressionTypes = expressionTypesBuilder.build();
 
             List<Type> tableTypes = update.getAssignments().stream()
-                    .map(assignment -> requireNonNull(columns.get(assignment.getName().getValue())))
+                    .map(assignment -> requireNonNull(columns.get(assignment.getName().getValue().toLowerCase(ENGLISH))))
                     .map(ColumnSchema::getType)
                     .collect(toImmutableList());
 
diff --git a/core/trino-main/src/main/java/io/trino/sql/planner/QueryPlanner.java b/core/trino-main/src/main/java/io/trino/sql/planner/QueryPlanner.java
index d00f50e6dbb8..68be174117d0 100644
--- a/core/trino-main/src/main/java/io/trino/sql/planner/QueryPlanner.java
+++ b/core/trino-main/src/main/java/io/trino/sql/planner/QueryPlanner.java
@@ -177,6 +177,7 @@
 import static io.trino.type.IntervalDayTimeType.INTERVAL_DAY_TIME;
 import static io.trino.type.IntervalYearMonthType.INTERVAL_YEAR_MONTH;
 import static java.lang.String.format;
+import static java.util.Locale.ENGLISH;
 import static java.util.Objects.requireNonNull;
 
 class QueryPlanner
@@ -600,7 +601,7 @@ public PlanNode plan(Update node)
 
         Expression[] orderedColumnValuesArray = new Expression[updatedColumnHandles.size()];
         node.getAssignments().forEach(assignment -> {
-            String name = assignment.getName().getValue();
+            String name = assignment.getName().getValue().toLowerCase(ENGLISH);
             ColumnHandle handle = nameToHandle.get(name);
             int index = updatedColumnHandles.indexOf(handle);
             if (index >= 0) {
diff --git a/plugin/trino-hive/src/test/java/io/trino/plugin/hive/BaseHiveConnectorTest.java b/plugin/trino-hive/src/test/java/io/trino/plugin/hive/BaseHiveConnectorTest.java
index 9e58658d6186..d54ffc30a115 100644
--- a/plugin/trino-hive/src/test/java/io/trino/plugin/hive/BaseHiveConnectorTest.java
+++ b/plugin/trino-hive/src/test/java/io/trino/plugin/hive/BaseHiveConnectorTest.java
@@ -342,6 +342,14 @@ public void testUpdate()
                 .hasMessage(MODIFYING_NON_TRANSACTIONAL_TABLE_MESSAGE);
     }
 
+    @Override
+    public void testUpdateCaseSensitivity()
+    {
+        assertThatThrownBy(super::testUpdateCaseSensitivity)
+                .hasMessage(MODIFYING_NON_TRANSACTIONAL_TABLE_MESSAGE);
+    }
+
+    @Test
     @Override
     public void testUpdateRowConcurrently()
             throws Exception
diff --git a/plugin/trino-kudu/src/test/java/io/trino/plugin/kudu/TestKuduConnectorTest.java b/plugin/trino-kudu/src/test/java/io/trino/plugin/kudu/TestKuduConnectorTest.java
index 6fb5b5557a85..b0e41a9613cf 100644
--- a/plugin/trino-kudu/src/test/java/io/trino/plugin/kudu/TestKuduConnectorTest.java
+++ b/plugin/trino-kudu/src/test/java/io/trino/plugin/kudu/TestKuduConnectorTest.java
@@ -990,6 +990,15 @@ public void testUpdate()
         });
     }
 
+    /**
+     * This test fails intermittently because Kudu doesn't have strong enough
+     * semantics to support writing from multiple threads.
+     */
+    @Test(enabled = false)
+    @Override
+    public void testUpdateCaseSensitivity() {}
+
+    @Test
     @Override
     public void testUpdateRowConcurrently()
             throws Exception
diff --git a/testing/trino-testing/src/main/java/io/trino/testing/BaseConnectorTest.java b/testing/trino-testing/src/main/java/io/trino/testing/BaseConnectorTest.java
index d566126a54aa..5f157c1ea578 100644
--- a/testing/trino-testing/src/main/java/io/trino/testing/BaseConnectorTest.java
+++ b/testing/trino-testing/src/main/java/io/trino/testing/BaseConnectorTest.java
@@ -4651,6 +4651,17 @@ public void testUpdate()
         }
     }
 
+    @Test
+    public void testUpdateCaseSensitivity()
+    {
+        skipTestUnless(hasBehavior(SUPPORTS_UPDATE));
+
+        try (TestTable table = new TestTable(getQueryRunner()::execute, "test_row_update", "AS SELECT * FROM nation")) {
+            assertUpdate("UPDATE " + table.getName() + " SET NATIONKEY = 100 WHERE REGIONKEY = 2", 5);
+            assertQuery("SELECT count(*) FROM " + table.getName() + " WHERE nationkey = 100", "VALUES 5");
+        }
+    }
+
     // Repeat test with invocationCount for better test coverage, since the tested aspect is inherently non-deterministic.
     @Test(timeOut = 60_000, invocationCount = 4)
     public void testUpdateRowConcurrently()