tmp_hn0zvwd

# -*- coding: utf-8 -*-
"""
Created on Fri Jul 31 13:21:58 2020

@author: Artemio Soto-Breceda [artemios]

Estimation
----------
Runs the state/parameter estimation and plots results for a single channel 
at a time

Written for MATLAB by:
    Dean Freestone, Philippa Karoly 2016

This code is licensed under the MIT License 2018

"""
import numpy as np
import mat73 # To load Matlab v7.3 and later data files
import matplotlib.pyplot as plt
 
# Local functions
from nmm import set_params, g, propagate_metrics
 
mat = mat73.loadmat('./data/Seizure_1.mat') # Load the data. Change this file for alternative data
Seizure = mat["Seizure"] # 16 Channels

# Chose a channel, or loop through the 16
iCh = 1;    # Setting channel manually
print('Channel %02d ...' % iCh) # Print current channel

# Initialize input
ext_input = 300 # External input
input_offset = np.empty(0)

# Generate some data
time = 5
Fs = 0.4e3

# Parameter initialization
params = set_params(ext_input, input_offset, time,Fs)

if input_offset.size > 0:
    # Reset the offset
    my = np.mean(params['y'])
    input_offset = np.array([-my/0.0325]) # Scale (mV) to convert constant input to a steady-state effect on pyramidal membrane. NB DIVIDE BY 10e3 for VOLTS
    params = set_params(ext_input, input_offset)
    
# Retrive parameters into single variables
A = params['A']
B = params['B']
C = params['C']
H = params['H']
N_inputs = params['N_inputs']
N_samples = params['N_samples']
N_states = params['N_states']
N_syn = params['N_syn']
Q = params['Q']
R = params['R']
v0 = params['v0']
varsigma = params['varsigma']
xi = params['xi']
y = params['y']

xi_hat_init = np.mean( params['xi'][:, np.int(np.round(N_samples/2))-1:] , axis = 1)
P_hat_init = 10 * np.cov(params['xi'][:, np.int(np.round(N_samples/2))-1:])
P_hat_init[2*N_syn:, 2*N_syn:] = np.eye(N_syn + N_inputs) * 10e-2

# Set initial conditions for the Kalman Filter
xi_hat = np.zeros([N_states, N_samples])
P_hat = np.zeros([N_states, N_states, N_samples])
P_diag = np.zeros([N_states, N_samples])
                   
xi_hat[:,0] = xi_hat_init
P_hat[:,:,0] = P_hat_init

anneal_on = 1 # Nice!
kappa_0 = 10000
T_end_anneal = N_samples/20

# Loop through all (16) channels. <Hardcoded to 1 at the moment> Loop not implemented.
iCh = 1

print('Channel ...', iCh)

# Get one channel at a time
# NB - portal data is inverted. We need to scale it to some 'reasonable'
# range for the model, but still capture amplitude differences between
# seizures
y = -0.5 * Seizure[:, iCh-1:iCh]
N_samples = y.size

for t in range(1,N_samples):
    xi_0p = xi_hat[:, t-1]
    P_0p = P_hat[:, :, t-1]
    
    # Predict
    metrics = propagate_metrics(N_syn, N_states, N_inputs, A, B, C, P_0p, xi_0p, varsigma, v0, Q)
    xi_1m = metrics['xi_1m']
    P_1m = metrics['P_1m']
    
    if (t <= T_end_anneal) & (anneal_on):
        kappa = pow(kappa_0, (T_end_anneal-t)/(T_end_anneal-1))
    else:
        kappa = 1
        
    # K = P_1m*H'/(H*P_1m*H' + kappa*R);