diff --git a/lib/arguments/file-url.js b/lib/arguments/file-url.js
index 6c4ea9a2d9..448f703717 100644
--- a/lib/arguments/file-url.js
+++ b/lib/arguments/file-url.js
@@ -2,7 +2,7 @@ import {fileURLToPath} from 'node:url';
 
 // Allow some arguments/options to be either a file path string or a file URL
 export const safeNormalizeFileUrl = (file, name) => {
-	const fileString = normalizeFileUrl(file);
+	const fileString = normalizeFileUrl(normalizeDenoExecPath(file));
 
 	if (typeof fileString !== 'string') {
 		throw new TypeError(`${name} must be a string or a file URL: ${fileString}.`);
@@ -11,5 +11,15 @@ export const safeNormalizeFileUrl = (file, name) => {
 	return fileString;
 };
 
+// In Deno node:process execPath is a special object, not just a string:
+// https://github.com/denoland/deno/blob/f460188e583f00144000aa0d8ade08218d47c3c1/ext/node/polyfills/process.ts#L344
+const normalizeDenoExecPath = file => isDenoExecPath(file)
+	? file.toString()
+	: file;
+
+export const isDenoExecPath = file => typeof file !== 'string'
+	&& file
+	&& Object.getPrototypeOf(file) === String.prototype;
+
 // Same but also allows other values, e.g. `boolean` for the `shell` option
 export const normalizeFileUrl = file => file instanceof URL ? fileURLToPath(file) : file;
diff --git a/lib/pipe/pipe-arguments.js b/lib/pipe/pipe-arguments.js
index a1c9e58dd4..9745a9e7a7 100644
--- a/lib/pipe/pipe-arguments.js
+++ b/lib/pipe/pipe-arguments.js
@@ -1,6 +1,7 @@
 import {normalizeParameters} from '../methods/parameters.js';
 import {getStartTime} from '../return/duration.js';
 import {SUBPROCESS_OPTIONS, getToStream, getFromStream} from '../arguments/fd-options.js';
+import {isDenoExecPath} from '../arguments/file-url.js';
 
 // Normalize and validate arguments passed to `source.pipe(destination)`
 export const normalizePipeArguments = ({source, sourcePromise, boundOptions, createNested}, ...pipeArguments) => {
@@ -56,7 +57,7 @@ const getDestination = (boundOptions, createNested, firstArgument, ...pipeArgume
 		return {destination, pipeOptions: boundOptions};
 	}
 
-	if (typeof firstArgument === 'string' || firstArgument instanceof URL) {
+	if (typeof firstArgument === 'string' || firstArgument instanceof URL || isDenoExecPath(firstArgument)) {
 		if (Object.keys(boundOptions).length > 0) {
 			throw new TypeError('Please use .pipe("file", ..., options) or .pipe(execa("file", ..., options)) instead of .pipe(options)("file", ...).');
 		}
diff --git a/test/helpers/file-path.js b/test/helpers/file-path.js
index dea9fa97e3..db4032ff38 100644
--- a/test/helpers/file-path.js
+++ b/test/helpers/file-path.js
@@ -1,4 +1,15 @@
 import path from 'node:path';
+import process from 'node:process';
 
 export const getAbsolutePath = file => ({file});
 export const getRelativePath = filePath => ({file: path.relative('.', filePath)});
+// Defined as getter so call to toString is not cached
+export const getDenoNodePath = () => Object.freeze({
+	__proto__: String.prototype,
+	toString() {
+		return process.execPath;
+	},
+	get length() {
+		return this.toString().length;
+	},
+});
diff --git a/test/methods/node.js b/test/methods/node.js
index 05eff2ec06..a9bca52933 100644
--- a/test/methods/node.js
+++ b/test/methods/node.js
@@ -7,6 +7,7 @@ import {execa, execaSync, execaNode} from '../../index.js';
 import {FIXTURES_DIRECTORY} from '../helpers/fixtures-directory.js';
 import {identity, fullStdio} from '../helpers/stdio.js';
 import {foobarString} from '../helpers/input.js';
+import {getDenoNodePath} from '../helpers/file-path.js';
 
 process.chdir(FIXTURES_DIRECTORY);
 
@@ -73,6 +74,9 @@ test('Cannot use "node" as binary - "node" option sync', testDoubleNode, 'node',
 test('Cannot use path to "node" as binary - execaNode()', testDoubleNode, process.execPath, execaNode);
 test('Cannot use path to "node" as binary - "node" option', testDoubleNode, process.execPath, runWithNodeOption);
 test('Cannot use path to "node" as binary - "node" option sync', testDoubleNode, process.execPath, runWithNodeOptionSync);
+test('Cannot use deno style nodePath as binary - execaNode()', testDoubleNode, getDenoNodePath(), execaNode);
+test('Cannot use deno style nodePath as binary - "node" option', testDoubleNode, getDenoNodePath(), runWithNodeOption);
+test('Cannot use deno style nodePath as binary - "node" option sync', testDoubleNode, getDenoNodePath(), runWithNodeOptionSync);
 
 const getNodePath = async () => {
 	const {path} = await getNode(TEST_NODE_VERSION);
@@ -174,6 +178,16 @@ test.serial('The "nodePath" option is relative to "cwd" - execaNode()', testCwdN
 test.serial('The "nodePath" option is relative to "cwd" - "node" option', testCwdNodePath, runWithNodeOption);
 test.serial('The "nodePath" option is relative to "cwd" - "node" option sync', testCwdNodePath, runWithNodeOptionSync);
 
+const testDenoExecPath = async (t, execaMethod) => {
+	const {exitCode, stdout} = await execaMethod('noop.js', [], {nodePath: getDenoNodePath()});
+	t.is(exitCode, 0);
+	t.is(stdout, foobarString);
+};
+
+test('The deno style "nodePath" option can be used - execaNode()', testDenoExecPath, execaNode);
+test('The deno style "nodePath" option can be used - "node" option', testDenoExecPath, runWithNodeOption);
+test('The deno style "nodePath" option can be used - "node" option sync', testDenoExecPath, runWithNodeOptionSync);
+
 const testNodeOptions = async (t, execaMethod) => {
 	const {stdout} = await execaMethod('empty.js', [], {nodeOptions: ['--version']});
 	t.is(stdout, process.version);
diff --git a/test/pipe/pipe-arguments.js b/test/pipe/pipe-arguments.js
index 291eb0728f..60a17401d0 100644
--- a/test/pipe/pipe-arguments.js
+++ b/test/pipe/pipe-arguments.js
@@ -4,6 +4,7 @@ import test from 'ava';
 import {$, execa} from '../../index.js';
 import {setFixtureDirectory, FIXTURES_DIRECTORY} from '../helpers/fixtures-directory.js';
 import {foobarString} from '../helpers/input.js';
+import {getDenoNodePath} from '../helpers/file-path.js';
 
 setFixtureDirectory();
 
@@ -73,6 +74,16 @@ test('execa.$.pipe("file", commandArguments, options)`', async t => {
 	t.is(stdout, foobarString);
 });
 
+test('execa.$.pipe("file", commandArguments, options with denoNodePath)`', async t => {
+	const {stdout} = await execa('noop.js', [foobarString]).pipe('node', ['stdin.js'], {cwd: FIXTURES_DIRECTORY, nodePath: getDenoNodePath()});
+	t.is(stdout, foobarString);
+});
+
+test('execa.$.pipe("file", commandArguments, denoNodePath)`', async t => {
+	const {stdout} = await execa('noop.js', [foobarString]).pipe(getDenoNodePath(), ['stdin.js'], {cwd: FIXTURES_DIRECTORY});
+	t.is(stdout, foobarString);
+});
+
 test('$.pipe.pipe("file", commandArguments, options)', async t => {
 	const {stdout} = await $`noop.js ${foobarString}`
 		.pipe`stdin.js`