diff --git a/CHANGES.rst b/CHANGES.rst
index ced5a8358d..18fde40105 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -4,6 +4,7 @@ Changelog
 2.6.0 (unreleased)
 ------------------
 
+- #2672 Fix rejected sample analyses are re-added on profile removal
 - #2670 Flush calculated result if dependency is flushed
 - #2667 Specifications support for multi-result analyses
 - #2668 Paste support for select components in sample add form
diff --git a/src/bika/lims/content/analysisrequest.py b/src/bika/lims/content/analysisrequest.py
index e0b0216445..1fbb86c8e2 100644
--- a/src/bika/lims/content/analysisrequest.py
+++ b/src/bika/lims/content/analysisrequest.py
@@ -1516,7 +1516,10 @@ def setProfiles(self, value):
 
         # Don't add analyses from profiles during sample creation.
         # In this case the required analyses are added afterwards explicitly.
-        if not api.is_temporary(self):
+        #
+        # Also only add analyses if a profile (value) is selected:
+        # https://github.com/senaite/senaite.core/pull/2672
+        if value and not api.is_temporary(self):
             # get the profiles
             profiles = map(api.get_object_by_uid, uids)
             # get the current set of analyses/services