Hello,
I have a question regarding the usage of decoupleR.
In my dataset, multiple Ensembl gene IDs map to the same gene symbol, so there are duplicated symbols in the expression matrix. When I run run_ulm() with these duplicated rownames, the function executes without any error.
My questions are:
In this situation, are the duplicated gene symbols handled correctly by run_ulm()?
Would you recommend aggregating (e.g., summing or averaging) the expression values for duplicated symbols before running run_ulm() to ensure more accurate results?
Thank you very much for your help and for developing such a useful package.
Best regards,
Hello,
I have a question regarding the usage of decoupleR.
In my dataset, multiple Ensembl gene IDs map to the same gene symbol, so there are duplicated symbols in the expression matrix. When I run run_ulm() with these duplicated rownames, the function executes without any error.
My questions are:
In this situation, are the duplicated gene symbols handled correctly by run_ulm()?
Would you recommend aggregating (e.g., summing or averaging) the expression values for duplicated symbols before running run_ulm() to ensure more accurate results?
Thank you very much for your help and for developing such a useful package.
Best regards,