diff --git a/mypyc/irbuild/expression.py b/mypyc/irbuild/expression.py
index 59ecc4ac2c5c..d881bd017fc9 100644
--- a/mypyc/irbuild/expression.py
+++ b/mypyc/irbuild/expression.py
@@ -10,6 +10,7 @@
 from collections.abc import Sequence
 from typing import Callable
 
+from mypy.checkexpr import try_getting_literal
 from mypy.nodes import (
     ARG_NAMED,
     ARG_POS,
@@ -50,7 +51,7 @@
     UnaryExpr,
     Var,
 )
-from mypy.types import Instance, ProperType, TupleType, TypeType, get_proper_type
+from mypy.types import Instance, LiteralType, ProperType, TupleType, TypeType, get_proper_type
 from mypyc.common import MAX_SHORT_INT
 from mypyc.ir.class_ir import ClassIR
 from mypyc.ir.func_ir import FUNC_CLASSMETHOD, FUNC_STATICMETHOD
@@ -784,9 +785,26 @@ def try_specialize_in_expr(
         items = [builder.accept(item) for item in rhs.items]
     elif isinstance(builder.node_type(rhs), RTuple):
         left = builder.accept(lhs)
-        tuple_val = builder.accept(rhs)
-        assert isinstance(tuple_val.type, RTuple)
-        items = [builder.add(TupleGet(tuple_val, i)) for i in range(len(tuple_val.type.types))]
+        proper_type = get_proper_type(builder.types[rhs])
+        assert isinstance(proper_type, TupleType)
+        literal_items = list(map(try_getting_literal, proper_type.items))
+        if None not in literal_items:
+            # If all tuple items are literals we don't even need to accept the tuple
+            # TODO: should we use object_rprimitive? prob not, what do?
+            items = [LoadLiteral(literal.value, object_rprimitive) for literal in literal_items]
+        else:
+            tuple_val = builder.accept(rhs)
+            assert isinstance(tuple_val.type, RTuple)
+            proper_type = get_proper_type(builder.types[rhs])
+            items = [
+                # TODO: should we use object_rprimitive? prob not, what do?
+                (
+                    LoadLiteral(typ.value, object_rprimitive)
+                    if isinstance(typ, LiteralType)
+                    else builder.add(TupleGet(tuple_val, i))
+                )
+                for i, typ in enumerate(map(try_getting_literal, proper_type.items))
+            ]
 
     if items is not None:
         assert left is not None