diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 3efd927..cf05031 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -109,6 +109,9 @@ jobs:
           - name: PySide2
             tox: pyside2
             dependencies: qt5
+          - name: PySide6
+            tox: pyside6
+            dependencies: qt6
           - name: asyncio
             tox: asyncio
             dependencies: asyncio
@@ -121,6 +124,10 @@ jobs:
               major: 2
             reactor:
               tox: pyside2
+          - python:
+              major: 2
+            reactor:
+              tox: pyside6
           - python:
               major: 2
             reactor:
@@ -133,6 +140,10 @@ jobs:
               implementation: pypy
             reactor:
               tox: pyside2
+          - python:
+              implementation: pypy
+            reactor:
+              tox: pyside6
     steps:
       - uses: actions/checkout@v2
       - name: Enable Problem Matchers
@@ -173,6 +184,11 @@ jobs:
         run: |
           apt-get update --yes
           apt-get install --yes libgl1
+      - name: Install Linux Qt6 dependencies
+        if: matrix.os.python_platform == 'linux' && matrix.reactor.dependencies == 'qt6'
+        run: |
+          apt-get update --yes
+          apt-get install --yes libgl1 libegl1
       - name: Install
         run: |
           pip install tox
diff --git a/setup.py b/setup.py
index b380e7f..8d16bf3 100755
--- a/setup.py
+++ b/setup.py
@@ -21,6 +21,11 @@
             # >= 0.6.3 for PySide2 extra version constraints
             "qt5reactor[pyside2]>=0.6.3",
         ],
+        "pyside6": [
+            # TODO: specify version
+            # >= 0.6.x for PySide6 support
+            "qt5reactor[pyside6] @ git+https://github.com/sveinse/qt5reactor@feature-pyside6",
+        ],
         "pyqt5": ["qt5reactor[pyqt5]>=0.6.2"],
     },
     classifiers=[
diff --git a/tox.ini b/tox.ini
index cad52b0..a8d49a7 100644
--- a/tox.ini
+++ b/tox.ini
@@ -3,7 +3,7 @@ envlist=
     py{27,py27,35,36,37,38,39,py37,py38}-defaultreactor
     py{35,36,37,38,39,py37,py38}-asyncioreactor
     py{35,36,37,38,39}-pyqt5reactor
-    py{35,36,37,38,39}-pyside2reactor
+    py{35,36,37,38,39}-pyside{2,6}}reactor
     linting
 
 [testenv]
@@ -11,16 +11,18 @@ deps=
     greenlet
     pytest
     twisted
-    pyqt5reactor,pyside2reactor: pytest-qt
-    pyqt5reactor,pyside2reactor: pytest-xvfb
-    pyqt5reactor,pyside2reactor: pywin32; sys_platform == 'win32'
+    pyqt5reactor,pyside{2,6}reactor: pytest-qt
+    pyqt5reactor,pyside{2,6}reactor: pytest-xvfb
+    pyqt5reactor,pyside{2,6}reactor: pywin32; sys_platform == 'win32'
 extras=
     pyqt5reactor: pyqt5
     pyside2reactor: pyside2
+    pyside6reactor: pyside6
 setenv=
     defaultreactor: REACTOR = default
     pyqt5reactor: REACTOR = qt5reactor
     pyside2reactor: REACTOR = qt5reactor
+    pyside6reactor: REACTOR = qt5reactor
     asyncioreactor: REACTOR = asyncio
 commands=
     pytest --reactor={env:REACTOR}