diff --git a/jsonnet/components/cluster-monitoring-operator.libsonnet b/jsonnet/components/cluster-monitoring-operator.libsonnet
index c9d2b9b8f5..da209e5643 100644
--- a/jsonnet/components/cluster-monitoring-operator.libsonnet
+++ b/jsonnet/components/cluster-monitoring-operator.libsonnet
@@ -247,6 +247,11 @@ function(params) {
         resources: ['featuregates'],
         verbs: ['get', 'list', 'watch'],
       },
+      {
+        apiGroups: ['config.openshift.io'],
+        resources: ['clustermonitorings'],
+        verbs: ['get', 'list', 'watch'],
+      },
       {
         apiGroups: ['certificates.k8s.io'],
         resources: ['certificatesigningrequests'],
diff --git a/manifests/0000_50_cluster-monitoring-operator_02-role.yaml b/manifests/0000_50_cluster-monitoring-operator_02-role.yaml
index 2c5a2ec6aa..b78ef950fc 100644
--- a/manifests/0000_50_cluster-monitoring-operator_02-role.yaml
+++ b/manifests/0000_50_cluster-monitoring-operator_02-role.yaml
@@ -135,6 +135,14 @@ rules:
   - get
   - list
   - watch
+- apiGroups:
+  - config.openshift.io
+  resources:
+  - clustermonitorings
+  verbs:
+  - get
+  - list
+  - watch
 - apiGroups:
   - certificates.k8s.io
   resources:
diff --git a/manifests/0000_50_cluster-monitoring-operator_06-clusteroperator.yaml b/manifests/0000_50_cluster-monitoring-operator_06-clusteroperator.yaml
index d76a1747f6..5c3da8a36d 100644
--- a/manifests/0000_50_cluster-monitoring-operator_06-clusteroperator.yaml
+++ b/manifests/0000_50_cluster-monitoring-operator_06-clusteroperator.yaml
@@ -40,3 +40,6 @@ status:
     - group: monitoring.coreos.com
       name: ''
       resource: alertmanagerconfigs
+    - group: config.openshift.io
+      name: cluster
+      resource: clustermonitorings
diff --git a/pkg/client/client.go b/pkg/client/client.go
index e9058276f3..dc321d15c1 100644
--- a/pkg/client/client.go
+++ b/pkg/client/client.go
@@ -417,6 +417,19 @@ func (c *Client) ClusterOperatorListWatch(ctx context.Context, name string) *cac
 	}
 }
 
+func (c *Client) ClusterMonitoringListWatch(ctx context.Context) *cache.ListWatch {
+	clusterMonitoringInterface := c.oscclient.ConfigV1alpha1().ClusterMonitorings()
+
+	return &cache.ListWatch{
+		ListFunc: func(options metav1.ListOptions) (runtime.Object, error) {
+			return clusterMonitoringInterface.List(ctx, metav1.ListOptions{})
+		},
+		WatchFunc: func(options metav1.ListOptions) (watch.Interface, error) {
+			return clusterMonitoringInterface.Watch(ctx, options)
+		},
+	}
+}
+
 func (c *Client) HasRouteCapability(ctx context.Context) (bool, error) {
 	_, err := c.oscclient.ConfigV1().ClusterOperators().Get(ctx, "ingress", metav1.GetOptions{})
 	if apierrors.IsNotFound(err) {
diff --git a/pkg/operator/operator.go b/pkg/operator/operator.go
index 91f8e6ecc7..5f211d4153 100644
--- a/pkg/operator/operator.go
+++ b/pkg/operator/operator.go
@@ -24,6 +24,7 @@ import (
 
 	"github.com/blang/semver/v4"
 	configv1 "github.com/openshift/api/config/v1"
+	configv1alpha1 "github.com/openshift/api/config/v1alpha1"
 	"github.com/openshift/api/features"
 	configv1client "github.com/openshift/client-go/config/clientset/versioned"
 	configv1informers "github.com/openshift/client-go/config/informers/externalversions"
@@ -177,12 +178,13 @@ const (
 type Operator struct {
 	namespace, namespaceUserWorkload string
 
-	configMapName             string
-	userWorkloadConfigMapName string
-	images                    map[string]string
-	telemetryMatches          []string
-	remoteWrite               bool
-	CollectionProfilesEnabled bool
+	configMapName                  string
+	userWorkloadConfigMapName      string
+	images                         map[string]string
+	telemetryMatches               []string
+	remoteWrite                    bool
+	CollectionProfilesEnabled      bool
+	ClusterMonitoringConfigEnabled bool
 
 	lastKnowInfrastructureConfig *InfrastructureConfig
 	lastKnowProxyConfig          *ProxyConfig
@@ -452,10 +454,30 @@ func New(
 			return nil, err
 		}
 		o.CollectionProfilesEnabled = featureGates.Enabled(features.FeatureGateMetricsCollectionProfiles)
+		o.ClusterMonitoringConfigEnabled = featureGates.Enabled(features.FeatureGateClusterMonitoringConfig)
 	case <-time.After(1 * time.Minute):
 		return nil, fmt.Errorf("timed out waiting for FeatureGate detection")
 	}
 
+	// Watch the ClusterMonitoring config resource if the feature gate is enabled
+	if o.ClusterMonitoringConfigEnabled {
+		informer = cache.NewSharedIndexInformer(
+			o.client.ClusterMonitoringListWatch(ctx),
+			&configv1alpha1.ClusterMonitoring{},
+			resyncPeriod,
+			cache.Indexers{},
+		)
+		_, err = informer.AddEventHandler(cache.ResourceEventHandlerFuncs{
+			AddFunc:    o.handleEvent,
+			UpdateFunc: func(_, newObj interface{}) { o.handleEvent(newObj) },
+			DeleteFunc: o.handleEvent,
+		})
+		if err != nil {
+			return nil, err
+		}
+		o.informers = append(o.informers, informer)
+	}
+
 	// csrController runs a controller that requests a client TLS certificate
 	// for Prometheus k8s. This certificate is used to authenticate against the
 	// /metrics endpoint of the targets.
@@ -630,7 +652,8 @@ func (o *Operator) handleEvent(obj interface{}) {
 		*configv1.APIServer,
 		*configv1.Console,
 		*configv1.ClusterOperator,
-		*configv1.ClusterVersion:
+		*configv1.ClusterVersion,
+		*configv1alpha1.ClusterMonitoring:
 		// Log GroupKind and Name of the obj
 		rtObj := obj.(k8sruntime.Object)
 		gk := rtObj.GetObjectKind().GroupVersionKind().GroupKind()