update

Author: multitalk

README.md

@@ -68,4 +68,8 @@ An object of class scCrossTalk
 ```
 
 # About
-scCrossTalk was developed by Xin Shao. Should you have any questions, please contact Xin Shao at [email protected]
+scCrossTalk was used in our manuscript to dissect the different mechanism underlying cell-cell communications within the transplanted livers of EAD and non-EAD patients. 
+
+<img src='https://github.com/multitalk/scCrossTalk/blob/main/img/ccc.png'>
+
+(a, c) Cell-cell communications mediated by LR interactions in non-EAD and EAD patients, where the circle and heat plots displayed the number and score of LR pairs, respectively. (b, d) Comparison of the number and score of LR pairs between non-EAD and EAD patients with one-sided Welch¡¯s test. (e) Cell-cell communications represented by the number of LR pairs with ligands sent from hepatocytes and received by endothelial cells, MAIT cells, GZMB+ GZMK+ NK cells, and S100A12+ neutrophils. (f) Shared LR pairs underlying cell-cell communications among hepatocytes, endothelial cells, MAIT cells, GZMB+ GZMK+ NK cells, and S100A12+ neutrophils in non-EAD and EAD patients. (g) Cell-cell communications represented by the number of LR pairs with ligands sent from endothelial cells, MAIT cells, GZMB+ GZMK+ NK cells, and S100A12+ neutrophils and received by hepatocytes. (h) Top 10 LR pairs mediating cell-cell communications from hepatocytes and endothelial cells to endothelial cells, hepatocytes, MAIT cells, GZMB+ GZMK+ NK cells, and S100A12+ neutrophils in non-EAD and EAD patients. (i) Comparison of the expression of SAA1 in hepatocytes and FPR1 in S100A12+ neutrophils between non-EAD and EAD patients. (j) Expression of SAA1 and FPR1 among endothelial cells, hepatocytes, MAIT cells, GZMB+ GZMK+ NK cells, and S100A12+ neutrophils in non-EAD and EAD patients. (k) Top 100 DEGs of hepatocytes and the enriched pathways and biological processes between non-EAD and EAD patients. (l) Enriched hallmarks of TNF¦Á signaling via NFKB and bile acid metabolism by comparing EAD patients to non-EAD patients with GSEA.