__(a, c)__ Cell-cell communications mediated by LR interactions in non-EAD and EAD patients, where the circle and heat plots displayed the number and score of LR pairs, respectively. __(b, d)__ Comparison of the number and score of LR pairs between non-EAD and EAD patients with one-sided Welch¡¯s test. __(e)__ Cell-cell communications represented by the number of LR pairs with ligands sent from hepatocytes and received by endothelial cells, MAIT cells, GZMB+ GZMK+ NK cells, and S100A12+ neutrophils. (f) Shared LR pairs underlying cell-cell communications among hepatocytes, endothelial cells, MAIT cells, GZMB+ GZMK+ NK cells, and S100A12+ neutrophils in non-EAD and EAD patients. __(g)__ Cell-cell communications represented by the number of LR pairs with ligands sent from endothelial cells, MAIT cells, GZMB+ GZMK+ NK cells, and S100A12+ neutrophils and received by hepatocytes. __(h)__ Top 10 LR pairs mediating cell-cell communications from hepatocytes and endothelial cells to endothelial cells, hepatocytes, MAIT cells, GZMB+ GZMK+ NK cells, and S100A12+ neutrophils in non-EAD and EAD patients. __(i)__ Comparison of the expression of SAA1 in hepatocytes and FPR1 in S100A12+ neutrophils between non-EAD and EAD patients. __(j)__ Expression of SAA1 and FPR1 among endothelial cells, hepatocytes, MAIT cells, GZMB+ GZMK+ NK cells, and S100A12+ neutrophils in non-EAD and EAD patients. __(k)__ Top 100 DEGs of hepatocytes and the enriched pathways and biological processes between non-EAD and EAD patients. __(l)__ Enriched hallmarks of TNF¦Á signaling via NFKB and bile acid metabolism by comparing EAD patients to non-EAD patients with GSEA.
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