diff --git a/mite_data/data/MITE0000355.json b/mite_data/data/MITE0000355.json new file mode 100644 index 00000000..dc020665 --- /dev/null +++ b/mite_data/data/MITE0000355.json @@ -0,0 +1,57 @@ +{ + "accession": "MITE0000355", + "status": "active", + "comment": "Short-chain dehydrogenase/reductase", + "changelog": [ + { + "version": "1", + "date": "2026-05-16", + "contributors": [ + "0000-0002-0771-9611" + ], + "reviewers": [ + "0000-0001-6534-6609" + ], + "comment": "New entry. Reviewer 1 improved reaction description." + } + ], + "enzyme": { + "name": "AndC", + "description": "Dehydrogenase", + "references": [ + "doi:10.1021/ja508127q" + ], + "databaseIds": { + "uniprot": "A0A097ZPC9", + "genpept": "BAP81857.1", + "mibig": "BGC0002612" + } + }, + "reactions": [ + { + "tailoring": [ + "Oxidation" + ], + "description": "Oxidation of meroterpenoid intermediate in the anditomin biosynthetic pathway.", + "reactionSMARTS": "[#8]=[#6]1-[#6]2-[#6](=[#8])-[#6](-[#6])=[#6]3-[#8]-[#6@@]4(-[#6](-[#6]-[#6@]-3(/[#6])-[#6]=2-[#6]-[#8]-1)-[#6@]1(/[#6])-[#6](-[#6@@](-[#6@](-[#6]-[#6]-1)/[#8])(\\[#6])/[#6])-[#6]-[#6]-4)\\[#6]>>[#8]=[#6]1-[#6]2-[#6](=[#8])-[#6](-[#6])=[#6]3-[#8]-[#6@@]4(-[#6](-[#6]-[#6@]-3(/[#6])-[#6]=2-[#6]-[#8]-1)-[#6@]1(/[#6])-[#6](-[#6@@](-[#6](-[#6]-[#6]-1)=[#8])(\\[#6])/[#6])-[#6]-[#6]-4)\\[#6]", + "reactions": [ + { + "substrate": "CC1=C2O[C@@]3(C)CCC4C(C)(C)[C@@H](O)CC[C@]4(C)C3C[C@]2(C)C2=C(C(=O)OC2)C1=O", + "products": [ + "CC1=C2O[C@@]3(C)CCC4C(C)(C)C(=O)CC[C@]4(C)C3C[C@]2(C)C2=C(C(=O)OC2)C1=O" + ], + "isIntermediate": false, + "description": "Conversion of preandiloid A at C-3 hydroxyl to give preandiloid B." + } + ], + "evidence": { + "evidenceCode": [ + "Heterologous expression" + ], + "references": [ + "doi:10.1021/ja508127q" + ] + } + } + ] +}