diff --git a/mite_data/data/MITE0000354.json b/mite_data/data/MITE0000354.json new file mode 100644 index 00000000..78c0211a --- /dev/null +++ b/mite_data/data/MITE0000354.json @@ -0,0 +1,56 @@ +{ + "accession": "MITE0000354", + "status": "active", + "changelog": [ + { + "version": "1", + "date": "2026-05-16", + "contributors": [ + "0000-0002-0771-9611" + ], + "reviewers": [ + "0000-0001-6534-6609" + ], + "comment": "New entry. Reviewer 1 improed reaction descriptions." + } + ], + "enzyme": { + "name": "AndB", + "description": "Terpene cyclase", + "references": [ + "doi:10.1021/ja508127q" + ], + "databaseIds": { + "uniprot": "A0A097ZPD8", + "genpept": "BAP81856.1", + "mibig": "BGC0002612" + } + }, + "reactions": [ + { + "tailoring": [ + "Cyclization" + ], + "description": "Cyclization of the meroterpenoid intermediate in the anditomin biosynthetic pathway.", + "reactionSMARTS": "[#6]12-[#6](-[#8]-[#6]-[#6]=1-[#6@](/[#6]-[#6]=[#6](-[#6]-[#6]-[#6]=[#6](-[#6]-[#6]-[#6@@]1/[#8]-[#6]-1(-[#6])-[#6])-[#6])-[#6])(\\[#6])-[#6](=[#8])-[#6](-[#6])=[#6]-2-[#8])=[#8]>>[#8]=[#6]1-[#6]2-[#6](=[#8])-[#6](-[#6])=[#6]3-[#8]-[#6@@]4(-[#6](-[#6]-[#6@]-3(/[#6])-[#6]=2-[#6]-[#8]-1)-[#6@]1(/[#6])-[#6](-[#6@@](-[#6@](-[#6]-[#6]-1)/[#8])(\\[#6])/[#6])-[#6]-[#6]-4)\\[#6]", + "reactions": [ + { + "substrate": "CC(=CC[C@@]1(C)C(=O)C(C)=C(O)C2=C1COC2=O)CCC=C(C)CC[C@@H]1OC1(C)C", + "products": [ + "CC1=C2O[C@@]3(C)CCC4C(C)(C)[C@@H](O)CC[C@]4(C)C3C[C@]2(C)C2=C(C(=O)OC2)C1=O" + ], + "isIntermediate": false, + "description": "Converts epoxyfarnesyl-DHDMP to preandiloid A." + } + ], + "evidence": { + "evidenceCode": [ + "Heterologous expression" + ], + "references": [ + "doi:10.1021/ja508127q" + ] + } + } + ] +}