diff --git a/mite_data/data/MITE0000353.json b/mite_data/data/MITE0000353.json new file mode 100644 index 00000000..7e7dfdb7 --- /dev/null +++ b/mite_data/data/MITE0000353.json @@ -0,0 +1,61 @@ +{ + "accession": "MITE0000353", + "status": "active", + "changelog": [ + { + "version": "1", + "date": "2026-05-16", + "contributors": [ + "0000-0002-0771-9611" + ], + "reviewers": [ + "0000-0001-6534-6609" + ], + "comment": "New entry. Reviewer 1 improved reaction descriptions." + } + ], + "enzyme": { + "name": "AndE", + "description": "FAD-dependent epoxidase", + "references": [ + "doi:10.1021/ja508127q" + ], + "databaseIds": { + "uniprot": "A0A097ZPF7", + "genpept": "BAP81859.1", + "mibig": "BGC0002612" + }, + "cofactors": { + "organic": [ + "FAD" + ] + } + }, + "reactions": [ + { + "tailoring": [ + "Oxidation" + ], + "description": "Epoxidation of farnesyl-DHDMP to give epoxyfarnesyl-DHDMP in the anditomin biosynthetic pathway..", + "reactionSMARTS": "[#6]12-[#6](-[#8]-[#6]-[#6]=1-[#6@](/[#6]-[#6]=[#6](-[#6]-[#6]-[#6]=[#6](-[#6]-[#6]-[#6]=[#6](-[#6])-[#6])-[#6])-[#6])(\\[#6])-[#6](=[#8])-[#6](-[#6])=[#6]-2-[#8])=[#8]>>[#6]12-[#6](-[#8]-[#6]-[#6]=1-[#6@](/[#6]-[#6]=[#6](-[#6]-[#6]-[#6]=[#6](-[#6]-[#6]-[#6@@]1/[#8]-[#6]-1(-[#6])-[#6])-[#6])-[#6])(\\[#6])-[#6](=[#8])-[#6](-[#6])=[#6]-2-[#8])=[#8]", + "reactions": [ + { + "substrate": "CC(C)=CCCC(C)=CCCC(C)=CC[C@@]1(C)C(=O)C(C)=C(O)C2=C1COC2=O", + "products": [ + "CC(=CC[C@@]1(C)C(=O)C(C)=C(O)C2=C1COC2=O)CCC=C(C)CC[C@@H]1OC1(C)C" + ], + "isIntermediate": true, + "description": "Conversion of farnesyl-DHDMP to epoxyfarnesyl-DHDMP." + } + ], + "evidence": { + "evidenceCode": [ + "Heterologous expression" + ], + "references": [ + "doi:10.1021/ja508127q" + ] + } + } + ] +}