From dd5754cc4dc49cf09d42e472d3818e7b0944e37b Mon Sep 17 00:00:00 2001
From: mite-bot <zdoucmm@gmail.com>
Date: Fri, 15 May 2026 21:37:57 +0200
Subject: [PATCH 1/2] Add submission UUID file

---
 .../769a7f0a-5095-11f1-9ef6-bb4e59819b6d.json | 44 +++++++++++++++++++
 1 file changed, 44 insertions(+)
 create mode 100644 mite_data/data/769a7f0a-5095-11f1-9ef6-bb4e59819b6d.json

diff --git a/mite_data/data/769a7f0a-5095-11f1-9ef6-bb4e59819b6d.json b/mite_data/data/769a7f0a-5095-11f1-9ef6-bb4e59819b6d.json
new file mode 100644
index 00000000..b507f035
--- /dev/null
+++ b/mite_data/data/769a7f0a-5095-11f1-9ef6-bb4e59819b6d.json
@@ -0,0 +1,44 @@
+{
+    "accession": "MITE9999999",
+    "status": "pending",
+    "changelog": [
+        {
+            "version": "1",
+            "date": "2026-05-15",
+            "contributors": [
+                "0009-0005-2489-2079"
+            ],
+            "reviewers": [
+                "BBBBBBBBBBBBBBBBBBBBBBBB"
+            ],
+            "comment": "New entry."
+        }
+    ],
+    "enzyme": {
+        "name": "PrnB",
+        "databaseIds": {
+            "uniprot": "",
+            "genpept": "ABW69175.1"
+        },
+        "references": [
+            "doi:"
+        ]
+    },
+    "reactions": [
+        {
+            "evidence": {
+                "evidenceCode": [],
+                "references": [
+                    "doi:"
+                ]
+            },
+            "reactions": [
+                {
+                    "products": [
+                        ""
+                    ]
+                }
+            ]
+        }
+    ]
+}
\ No newline at end of file

From e8478e328716cbd00e8973f33e59aca138d759cb Mon Sep 17 00:00:00 2001
From: mite-bot <zdoucmm@gmail.com>
Date: Fri, 15 May 2026 22:28:58 +0200
Subject: [PATCH 2/2] Update submission

---
 .../769a7f0a-5095-11f1-9ef6-bb4e59819b6d.json | 58 ++++++++++++++-----
 1 file changed, 44 insertions(+), 14 deletions(-)

diff --git a/mite_data/data/769a7f0a-5095-11f1-9ef6-bb4e59819b6d.json b/mite_data/data/769a7f0a-5095-11f1-9ef6-bb4e59819b6d.json
index b507f035..0d9125d2 100644
--- a/mite_data/data/769a7f0a-5095-11f1-9ef6-bb4e59819b6d.json
+++ b/mite_data/data/769a7f0a-5095-11f1-9ef6-bb4e59819b6d.json
@@ -1,6 +1,7 @@
 {
     "accession": "MITE9999999",
     "status": "pending",
+    "comment": "Oxidative ring rearrangement and decarboxylation of 7-chloro-L-tryptophan to monodechloroaminopyrrolnitrin.",
     "changelog": [
         {
             "version": "1",
@@ -16,29 +17,58 @@
     ],
     "enzyme": {
         "name": "PrnB",
+        "description": "Heme-dependent oxygenase",
+        "references": [
+            "doi:10.1021/bi7012189"
+        ],
         "databaseIds": {
-            "uniprot": "",
-            "genpept": "ABW69175.1"
+            "uniprot": "P95481",
+            "genpept": "ABW69175.1",
+            "mibig": "BGC0000924"
         },
-        "references": [
-            "doi:"
-        ]
+        "cofactors": {
+            "organic": [
+                "Heme"
+            ]
+        }
     },
     "reactions": [
         {
-            "evidence": {
-                "evidenceCode": [],
-                "references": [
-                    "doi:"
-                ]
-            },
+            "tailoring": [
+                "Decarboxylation",
+                "Heterocyclization",
+                "Oxidation",
+                "Ring contraction"
+            ],
+            "description": "Oxidative indole ring rearrangement and decarboxylation of 7-chloro-L-tryptophan to monodechloroaminopyrrolnitrin.",
+            "reactionSMARTS": "N[C@@H](Cc1c[nH]c2c(Cl)cccc12)C(=O)O>>Nc1c(Cl)cccc1-c1cc[nH]c1",
             "reactions": [
                 {
+                    "substrate": "N[C@@H](Cc1c[nH]c2c(Cl)cccc12)C(=O)O",
                     "products": [
-                        ""
-                    ]
+                        "Nc1c(Cl)cccc1-c1cc[nH]c1"
+                    ],
+                    "isIntermediate": true,
+                    "description": "PrnB converts 7-chloro-L-tryptophan to monodechloroaminopyrrolnitrin by oxidative indole rearrangement and decarboxylation."
                 }
-            ]
+            ],
+            "evidence": {
+                "evidenceCode": [
+                    "Heterologous expression",
+                    "Inference from genomic data and chemical structure",
+                    "In vitro assay",
+                    "Knock-out studies",
+                    "Site-directed mutagenesis"
+                ],
+                "references": [
+                    "doi:10.1021/bi7012189",
+                    "doi:10.1074/jbc.M110.120485",
+                    "doi:10.1016/j.jbc.2024.108123"
+                ]
+            },
+            "databaseIds": {
+                "rhea": "50952"
+            }
         }
     ]
 }
\ No newline at end of file