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macs2 rule should handle PE better #345

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daler opened this issue Sep 3, 2021 · 0 comments
Open

macs2 rule should handle PE better #345

daler opened this issue Sep 3, 2021 · 0 comments

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@daler
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daler commented Sep 3, 2021

Currently, in order for macs2 to run in PE mode this line in the wrapper needs to be changed to BEDPE. This is awkward!

Some options:

  • expose a paired-end: parameter in the chipseq config section; this would be passed to the peak caller wrapper and handled by the wrapper. It should raise an error if the peak-caller does not support PE reads.
  • auto-detect from the BAM whether or not it's PE. I suppose this can be done by inspecting BAM flags, but I feel like specifying a parameter would be more explicit.
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