diff --git a/apps/node_man/exceptions.py b/apps/node_man/exceptions.py
index a1c7cb2a4..127e9ba3f 100644
--- a/apps/node_man/exceptions.py
+++ b/apps/node_man/exceptions.py
@@ -220,3 +220,9 @@ class YunTiPolicyConfigNotExistsError(NodeManBaseException):
     MESSAGE = _("云梯策略配置不存在")
     MESSAGE_TPL = _("云梯策略配置不存在")
     ERROR_CODE = 43
+
+
+class LimitAddHostError(NodeManBaseException):
+    MESSAGE = _("管控区域已被管理员限制新增主机")
+    MESSAGE_TPL = _("管控区域【ID：{id}】已被管理员限制新增主机【IP：{ip}】")
+    ERROR_CODE = 44
diff --git a/apps/node_man/handlers/validator.py b/apps/node_man/handlers/validator.py
index 7b31a5a00..f2e12b343 100644
--- a/apps/node_man/handlers/validator.py
+++ b/apps/node_man/handlers/validator.py
@@ -16,8 +16,9 @@
 from django.utils.translation import ugettext_lazy as _
 
 from apps.adapters.api.gse import get_gse_api_helper
+from apps.backend.components.collections.base import DBHelperMixin
 from apps.node_man import constants as const
-from apps.node_man import tools
+from apps.node_man import exceptions, models, tools
 from apps.node_man.exceptions import (
     ApIDNotExistsError,
     CloudNotExistError,
@@ -435,6 +436,16 @@ def install_validate(
     :param host_infos_gby_ip_key: DB中内网IP信息
     :return: 列表，ip被占用及其原因
     """
+    add_host_biz_blacklist: typing.List[int] = models.GlobalSettings.get_config(
+        models.GlobalSettings.KeyEnum.ADD_HOST_BIZ_BLACKLIST.value, default=[]
+    )
+    if job_type in const.JobType.INSTALL_AGENT:
+        for host in hosts:
+            except_bk_cloud_id = host.get("bk_cloud_id")
+            bk_biz_id = host.get("bk_biz_id")
+            if except_bk_cloud_id in DBHelperMixin().add_host_cloud_blacklist and bk_biz_id in add_host_biz_blacklist:
+                raise exceptions.LimitAddHostError(id=except_bk_cloud_id, ip=host["inner_ip"] or host["inner_ipv6"])
+
     accept_list = []
     ip_filter_list = []
     proxy_not_alive = []
diff --git a/apps/node_man/models.py b/apps/node_man/models.py
index 8dc074de9..7631312b8 100644
--- a/apps/node_man/models.py
+++ b/apps/node_man/models.py
@@ -170,6 +170,8 @@ class KeyEnum(Enum):
         INSTALL_CHANNEL_ID_NETWORK_SEGMENT = "INSTALL_CHANNEL_ID_NETWORK_SEGMENT"
         # 需要执行清理订阅的APP_CODE
         NEED_CLEAN_SUBSCRIPTION_APP_CODE = "NEED_CLEAN_SUBSCRIPTION_APP_CODE"
+        # 业务新增主机黑名单，用于限制指定业务通过安装 Agent 新增主机，配置样例：[1, 2]
+        ADD_HOST_BIZ_BLACKLIST = "ADD_HOST_BIZ_BLACKLIST"
 
     key = models.CharField(_("键"), max_length=255, db_index=True, primary_key=True)
     v_json = JSONField(_("值"))