Need help for the cofactor part

[Mnew1288]

Hi Suoqing,

Thanks for this amazing package!

I have recently started to work on a project with multiple conditions and want to understand the contribution of cofactors ( agonists, antagonists) to some pathways (WNT, BMP, et al). I checked the tutorials and couldn't find any clue. I can extract the cofactor information from the CellChatD, however, Is there any analysis we can do with the cofactors, just like the regular L-R interactions?

Thanks!

[Mnew1288]

Does anyone else understand the contribution of cofactors? I am completely lost. I checked the original Nature Communications paper and found no clue. The authors claimed, "the CellChatDB takes into account known composition of the ligand-receptor complexes, including complexes with multimeric ligands and receptors, as well as several cofactor types: soluble agonists, antagonists". I don't know whether there is a way to see the contribution of cofactors.