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Add module for Dorothea #13

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grst opened this issue Nov 17, 2021 · 0 comments
Open

Add module for Dorothea #13

grst opened this issue Nov 17, 2021 · 0 comments

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@grst
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grst commented Nov 17, 2021 •
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Dorothea is a method to call TF enrichment based on gene signatures. https://github.com/saezlab/dorothea

Input:

  • sample sheet
  • gene expression matrix

Output:

  • Plot
  • Table

I'm not sure if dorothea does proper statistical tests by group. If not, perform a simple statistical test, e.g. using a linear model.

Since it does not make sense to run dorothea on all datasets, this should be made optional (e.g. params.run_dorothea) and
be disabled by default.
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@grst