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Add narrowMatch EC xrefs to GO:0004198 calcium-dependent cysteine-type endopeptidase activity #29635

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sjm41 opened this issue Jan 31, 2025 · 0 comments
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@sjm41
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sjm41 commented Jan 31, 2025

I've been reviewing the 'Calpain' annotations in FlyBase.

Their activities are described by this term:

id: GO:0004198
name: calcium-dependent cysteine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
synonym: "calpain activity" NARROW []
is_a: GO:0004197 ! cysteine-type endopeptidase activity

  • Add EC:3.4.22.52, EC:3.4.22.53, EC:3.4.22.54 as narrowMatch xref to GO:0004198 (these correspond to calpain-1/2/3 EC entries)
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