NTR: NAD+-protein mono-ADP-ribosyltransferase activity

[rozaru]

• Suggested term label:

NAD+-protein mono-ADP-ribosyltransferase activity

• Definition (free text)

Catalysis of the reaction: Catalysis of the reaction: NAD(+) + acceptor = nicotinamide + ADP-D-ribosyl-acceptor + H(+).

• Reference, in format PMID:#######
  (REQUIRED)

• Gene product name and ID to be annotated to this term
  Drosophila Parp16

• Parent term(s)
  GO:1990404: NAD+-protein ADP-ribosyltransferase activity

• **Children terms
  GO:0140804 NAD+-protein-lysine ADP-ribosyltransferase activity
  GO:0140805 NAD+-protein-serine ADP-ribosyltransferase activity
  GO:0140815 NAD+-protein-histidine ADP-ribosyltransferase activity
  GO:0140802 NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity
  GO:0140803 NAD+-protein-cysteine ADP-ribosyltransferase activity
  GO:0140808 NAD+-protein-tyrosine ADP-ribosyltransferase activity
  GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity
  GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity
  GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity

• Synonyms (please specify, EXACT, BROAD, NARROW or RELATED)
  MARylation EXACT

• Cross-references

• For enzymes, please provide RHEA and/or EC numbers.

• Can also provide MetaCyc, KEGG, Wikipedia, and other links.

• Any other information
  There is a poly-ribosylation term (GO:0003950) but no term to describe general mono-ribosylation. The new term would act as a grouping terms for the specific GO terms (see children above) where the acceptor aa residue is known and allow to annotate ribosyltransferases that are responsible for mono-ribosylation but for which the aa acceptor is not known.
  This is the case for Parp16 in Dmel (PMID:27874829)