diff --git a/sqlmodel/main.py b/sqlmodel/main.py
index 7c916f79af..540c2ed05c 100644
--- a/sqlmodel/main.py
+++ b/sqlmodel/main.py
@@ -26,6 +26,7 @@
     cast,
     overload,
 )
+from typing import Annotated as TypingAnnotated
 
 from pydantic import BaseModel, EmailStr
 from pydantic.fields import FieldInfo as PydanticFieldInfo
@@ -54,7 +55,18 @@
 from sqlalchemy.orm.instrumentation import is_instrumented
 from sqlalchemy.sql.schema import MetaData
 from sqlalchemy.sql.sqltypes import LargeBinary, Time, Uuid
-from typing_extensions import Literal, TypeAlias, deprecated, get_origin
+from typing_extensions import (
+    Annotated as TEAnnotated,
+)
+from typing_extensions import (
+    Literal,
+    TypeAlias,
+    deprecated,
+    get_origin,
+)
+from typing_extensions import (
+    get_args as te_get_args,
+)
 
 from ._compat import (  # type: ignore[attr-defined]
     IS_PYDANTIC_V2,
@@ -546,6 +558,26 @@ def __new__(
             **new_cls.__annotations__,
         }
 
+        # For Pydantic v2: If a field used Annotated[..., Field(sa_column=Column(...))]
+        # Pydantic might not lift our custom attribute onto the final FieldInfo.
+        # Recover it from the original annotations before creating SQLAlchemy Columns.
+        if IS_PYDANTIC_V2:
+            for field_name, ann in original_annotations.items():
+                try:
+                    origin = get_origin(ann)
+                    if origin in (TEAnnotated, TypingAnnotated):
+                        for extra in te_get_args(ann)[1:]:
+                            sa_col = getattr(extra, "sa_column", Undefined)
+                            if isinstance(sa_col, Column):
+                                # Attach found Column to the Pydantic field info
+                                model_fields = get_model_fields(new_cls)
+                                if field_name in model_fields:
+                                    model_fields[field_name].sa_column = sa_col
+                                break
+                except Exception:
+                    # Best-effort; fall back to default behavior
+                    pass
+
         def get_config(name: str) -> Any:
             config_class_value = get_config_value(
                 model=new_cls, parameter=name, default=Undefined
@@ -562,6 +594,26 @@ def get_config(name: str) -> Any:
             # If it was passed by kwargs, ensure it's also set in config
             set_config_value(model=new_cls, parameter="table", value=config_table)
             for k, v in get_model_fields(new_cls).items():
+                # Prefer a Column passed via Annotated[..., Field(sa_column=...)]
+                if IS_PYDANTIC_V2:
+                    ann = original_annotations.get(k, None)
+                    if ann is not None:
+                        try:
+                            origin = get_origin(ann)
+                            if origin in (TEAnnotated, TypingAnnotated):
+                                for extra in te_get_args(ann)[1:]:
+                                    sa_col = getattr(extra, "sa_column", Undefined)
+                                    if isinstance(sa_col, Column):
+                                        setattr(new_cls, k, sa_col)
+                                        break
+                                else:
+                                    # no Column override found, build normally
+                                    col = get_column_from_field(v)
+                                    setattr(new_cls, k, col)
+                                continue
+                        except Exception:
+                            # Fall back to normal column building
+                            pass
                 col = get_column_from_field(v)
                 setattr(new_cls, k, col)
             # Set a config flag to tell FastAPI that this should be read with a field
@@ -709,6 +761,27 @@ def get_column_from_field(field: Any) -> Column:  # type: ignore
     else:
         field_info = field.field_info
     sa_column = getattr(field_info, "sa_column", Undefined)
+    # In Pydantic v2, when using Annotated[T, Field(...)], the Field(...) object
+    # is stored in the field's metadata and some custom attributes (like
+    # sa_column) might not be lifted onto the main FieldInfo. Inspect metadata
+    # to honor a Column passed via Annotated Field(...).
+    if IS_PYDANTIC_V2 and not isinstance(sa_column, Column):
+        # Try to recover a Column passed via Annotated[..., Field(sa_column=...)]
+        raw_ann = getattr(field, "annotation", None)
+        origin = get_origin(raw_ann)
+        if origin in (TEAnnotated, TypingAnnotated):
+            for extra in te_get_args(raw_ann)[1:]:
+                meta_sa_column = getattr(extra, "sa_column", Undefined)
+                if isinstance(meta_sa_column, Column):
+                    sa_column = meta_sa_column
+                    break
+        # Also check field metadata in case custom FieldInfo leaked through
+        if not isinstance(sa_column, Column):
+            for meta in getattr(field, "metadata", ()):
+                meta_sa_column = getattr(meta, "sa_column", Undefined)
+                if isinstance(meta_sa_column, Column):
+                    sa_column = meta_sa_column
+                    break
     if isinstance(sa_column, Column):
         return sa_column
     sa_type = get_sqlalchemy_type(field)
diff --git a/tests/test_field_sa_column.py b/tests/test_field_sa_column.py
index e2ccc6d7ef..7e739155dd 100644
--- a/tests/test_field_sa_column.py
+++ b/tests/test_field_sa_column.py
@@ -1,8 +1,12 @@
+from datetime import datetime
 from typing import Optional
 
 import pytest
-from sqlalchemy import Column, Integer, String
+from sqlalchemy import Column, DateTime, Integer, String
 from sqlmodel import Field, SQLModel
+from typing_extensions import Annotated
+
+from tests.conftest import needs_pydanticv2
 
 
 def test_sa_column_takes_precedence() -> None:
@@ -119,3 +123,16 @@ class Item(SQLModel, table=True):
                 sa_column=Column(Integer, primary_key=True),
                 ondelete="CASCADE",
             )
+
+
+@needs_pydanticv2
+def test_sa_column_in_annotated_is_respected() -> None:
+    class Item(SQLModel, table=True):
+        id: Optional[int] = Field(default=None, primary_key=True)
+        available_at: Annotated[
+            datetime, Field(sa_column=Column(DateTime(timezone=True)))
+        ]
+
+    # Should reflect timezone=True from the provided Column
+    assert isinstance(Item.available_at.type, DateTime)  # type: ignore[attr-defined]
+    assert Item.available_at.type.timezone is True  # type: ignore[attr-defined]