diff --git a/src/libraries/Microsoft.Extensions.Hosting/tests/UnitTests/Microsoft.Extensions.Hosting.Unit.Tests.csproj b/src/libraries/Microsoft.Extensions.Hosting/tests/UnitTests/Microsoft.Extensions.Hosting.Unit.Tests.csproj
index a2432e3dfd5a21..752465d819b9e1 100644
--- a/src/libraries/Microsoft.Extensions.Hosting/tests/UnitTests/Microsoft.Extensions.Hosting.Unit.Tests.csproj
+++ b/src/libraries/Microsoft.Extensions.Hosting/tests/UnitTests/Microsoft.Extensions.Hosting.Unit.Tests.csproj
@@ -31,7 +31,7 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 
 </Project>
diff --git a/src/libraries/System.Collections.NonGeneric/tests/System.Collections.NonGeneric.Tests.csproj b/src/libraries/System.Collections.NonGeneric/tests/System.Collections.NonGeneric.Tests.csproj
index 47f28878c7cdaa..427148b9d9573f 100644
--- a/src/libraries/System.Collections.NonGeneric/tests/System.Collections.NonGeneric.Tests.csproj
+++ b/src/libraries/System.Collections.NonGeneric/tests/System.Collections.NonGeneric.Tests.csproj
@@ -51,6 +51,6 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 </Project>
diff --git a/src/libraries/System.Collections.Specialized/tests/System.Collections.Specialized.Tests.csproj b/src/libraries/System.Collections.Specialized/tests/System.Collections.Specialized.Tests.csproj
index 5e5bff117baeca..82e963f0213112 100644
--- a/src/libraries/System.Collections.Specialized/tests/System.Collections.Specialized.Tests.csproj
+++ b/src/libraries/System.Collections.Specialized/tests/System.Collections.Specialized.Tests.csproj
@@ -82,6 +82,6 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 </Project>
diff --git a/src/libraries/System.Collections/tests/System.Collections.Tests.csproj b/src/libraries/System.Collections/tests/System.Collections.Tests.csproj
index 47a53a0fa4d253..8d33efddb1c9ed 100644
--- a/src/libraries/System.Collections/tests/System.Collections.Tests.csproj
+++ b/src/libraries/System.Collections/tests/System.Collections.Tests.csproj
@@ -9,7 +9,7 @@
   </PropertyGroup>
   <ItemGroup>
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
-    <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj" Private="true" SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+    <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj" Private="true" SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
   <ItemGroup>
     <RdXmlFile Include="default.rd.xml" />
diff --git a/src/libraries/System.ComponentModel.Annotations/tests/System.ComponentModel.Annotations.Tests.csproj b/src/libraries/System.ComponentModel.Annotations/tests/System.ComponentModel.Annotations.Tests.csproj
index 19bfeb9f124584..513cf333dc3919 100644
--- a/src/libraries/System.ComponentModel.Annotations/tests/System.ComponentModel.Annotations.Tests.csproj
+++ b/src/libraries/System.ComponentModel.Annotations/tests/System.ComponentModel.Annotations.Tests.csproj
@@ -55,6 +55,6 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 </Project>
diff --git a/src/libraries/System.ComponentModel.Primitives/tests/System.ComponentModel.Primitives.Tests.csproj b/src/libraries/System.ComponentModel.Primitives/tests/System.ComponentModel.Primitives.Tests.csproj
index 7576178720ec79..a008a90b972cef 100644
--- a/src/libraries/System.ComponentModel.Primitives/tests/System.ComponentModel.Primitives.Tests.csproj
+++ b/src/libraries/System.ComponentModel.Primitives/tests/System.ComponentModel.Primitives.Tests.csproj
@@ -33,6 +33,6 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 </Project>
\ No newline at end of file
diff --git a/src/libraries/System.ComponentModel.TypeConverter/tests/System.ComponentModel.TypeConverter.Tests.csproj b/src/libraries/System.ComponentModel.TypeConverter/tests/System.ComponentModel.TypeConverter.Tests.csproj
index 8f9add9374dc7a..896c4c15eba2ef 100644
--- a/src/libraries/System.ComponentModel.TypeConverter/tests/System.ComponentModel.TypeConverter.Tests.csproj
+++ b/src/libraries/System.ComponentModel.TypeConverter/tests/System.ComponentModel.TypeConverter.Tests.csproj
@@ -177,7 +177,7 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
   <ItemGroup>
     <EmbeddedResource Include="Resources\TestResx.resx">
diff --git a/src/libraries/System.Configuration.ConfigurationManager/tests/System.Configuration.ConfigurationManager.Tests.csproj b/src/libraries/System.Configuration.ConfigurationManager/tests/System.Configuration.ConfigurationManager.Tests.csproj
index bde8867905826f..a40157aaaeefda 100644
--- a/src/libraries/System.Configuration.ConfigurationManager/tests/System.Configuration.ConfigurationManager.Tests.csproj
+++ b/src/libraries/System.Configuration.ConfigurationManager/tests/System.Configuration.ConfigurationManager.Tests.csproj
@@ -118,6 +118,6 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 </Project>
diff --git a/src/libraries/System.Data.Common/tests/System.Data.Common.Tests.csproj b/src/libraries/System.Data.Common/tests/System.Data.Common.Tests.csproj
index be24b75825d31b..3e64078764be67 100644
--- a/src/libraries/System.Data.Common/tests/System.Data.Common.Tests.csproj
+++ b/src/libraries/System.Data.Common/tests/System.Data.Common.Tests.csproj
@@ -125,7 +125,7 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
   <!-- S.D.SqlClient isn't live built anymore. -->
   <ItemGroup>
diff --git a/src/libraries/System.Formats.Nrbf/tests/System.Formats.Nrbf.Tests.csproj b/src/libraries/System.Formats.Nrbf/tests/System.Formats.Nrbf.Tests.csproj
index 0ed91d1cce808f..f106fcdf2ec491 100644
--- a/src/libraries/System.Formats.Nrbf/tests/System.Formats.Nrbf.Tests.csproj
+++ b/src/libraries/System.Formats.Nrbf/tests/System.Formats.Nrbf.Tests.csproj
@@ -29,7 +29,7 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 
 </Project>
diff --git a/src/libraries/System.Net.Requests/tests/System.Net.Requests.Tests.csproj b/src/libraries/System.Net.Requests/tests/System.Net.Requests.Tests.csproj
index 04729133d6747f..e964bb194a147a 100644
--- a/src/libraries/System.Net.Requests/tests/System.Net.Requests.Tests.csproj
+++ b/src/libraries/System.Net.Requests/tests/System.Net.Requests.Tests.csproj
@@ -59,6 +59,6 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 </Project>
diff --git a/src/libraries/System.Net.Security/tests/FunctionalTests/System.Net.Security.Tests.csproj b/src/libraries/System.Net.Security/tests/FunctionalTests/System.Net.Security.Tests.csproj
index 8cca9ec340c6a2..0aee7760ef01b7 100644
--- a/src/libraries/System.Net.Security/tests/FunctionalTests/System.Net.Security.Tests.csproj
+++ b/src/libraries/System.Net.Security/tests/FunctionalTests/System.Net.Security.Tests.csproj
@@ -185,6 +185,6 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 </Project>
diff --git a/src/libraries/System.ObjectModel/tests/System.ObjectModel.Tests.csproj b/src/libraries/System.ObjectModel/tests/System.ObjectModel.Tests.csproj
index 59d55424d93e2a..620fc51d4e90d8 100644
--- a/src/libraries/System.ObjectModel/tests/System.ObjectModel.Tests.csproj
+++ b/src/libraries/System.ObjectModel/tests/System.ObjectModel.Tests.csproj
@@ -49,6 +49,6 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 </Project>
diff --git a/src/libraries/System.Reflection.Metadata/tests/System.Reflection.Metadata.Tests.csproj b/src/libraries/System.Reflection.Metadata/tests/System.Reflection.Metadata.Tests.csproj
index c87d9b4a6f2502..5ebd036386197b 100644
--- a/src/libraries/System.Reflection.Metadata/tests/System.Reflection.Metadata.Tests.csproj
+++ b/src/libraries/System.Reflection.Metadata/tests/System.Reflection.Metadata.Tests.csproj
@@ -157,7 +157,7 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 
   <ItemGroup Condition="'$(TargetOS)' == 'browser'">
diff --git a/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/System.Resources.Extensions.BinaryFormat.Tests.csproj b/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/System.Resources.Extensions.BinaryFormat.Tests.csproj
index 6dc735eada0088..5e47d695d98d9c 100644
--- a/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/System.Resources.Extensions.BinaryFormat.Tests.csproj
+++ b/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/System.Resources.Extensions.BinaryFormat.Tests.csproj
@@ -45,7 +45,7 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 
   <ItemGroup>
diff --git a/src/libraries/System.Resources.Extensions/tests/CompatTests/System.Resources.Extensions.Compat.Tests.csproj b/src/libraries/System.Resources.Extensions/tests/CompatTests/System.Resources.Extensions.Compat.Tests.csproj
index 2ad693090b8927..4075c7c4811d1b 100644
--- a/src/libraries/System.Resources.Extensions/tests/CompatTests/System.Resources.Extensions.Compat.Tests.csproj
+++ b/src/libraries/System.Resources.Extensions/tests/CompatTests/System.Resources.Extensions.Compat.Tests.csproj
@@ -31,7 +31,7 @@
         <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
     <ProjectReference Include="$(LibrariesProjectRoot)System.Windows.Extensions\src\System.Windows.Extensions.csproj" Condition="'$(TargetPlatformIdentifier)' == 'windows'" />
   </ItemGroup>
 
diff --git a/src/libraries/System.Resources.Extensions/tests/System.Resources.Extensions.Tests.csproj b/src/libraries/System.Resources.Extensions/tests/System.Resources.Extensions.Tests.csproj
index 26c2a0f0b46de5..07ab7d8ee3f0db 100644
--- a/src/libraries/System.Resources.Extensions/tests/System.Resources.Extensions.Tests.csproj
+++ b/src/libraries/System.Resources.Extensions/tests/System.Resources.Extensions.Tests.csproj
@@ -31,7 +31,7 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
     <ProjectReference Include="$(LibrariesProjectRoot)System.Windows.Extensions\src\System.Windows.Extensions.csproj" Condition="'$(TargetPlatformIdentifier)' == 'windows'" />
   </ItemGroup>
 
diff --git a/src/libraries/System.Runtime.Serialization.Formatters/tests/System.Runtime.Serialization.Formatters.Tests.csproj b/src/libraries/System.Runtime.Serialization.Formatters/tests/System.Runtime.Serialization.Formatters.Tests.csproj
index 5c948623440fbc..ec5d94e6c95e8f 100644
--- a/src/libraries/System.Runtime.Serialization.Formatters/tests/System.Runtime.Serialization.Formatters.Tests.csproj
+++ b/src/libraries/System.Runtime.Serialization.Formatters/tests/System.Runtime.Serialization.Formatters.Tests.csproj
@@ -58,7 +58,7 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
   <ItemGroup Condition="'$(TargetFrameworkIdentifier)' == '.NETFramework'">
     <ProjectReference Include="$(LibrariesProjectRoot)System.Reflection.Metadata\src\System.Reflection.Metadata.csproj" />
diff --git a/src/libraries/System.Runtime.Serialization.Primitives/tests/System.Runtime.Serialization.Primitives.Tests.csproj b/src/libraries/System.Runtime.Serialization.Primitives/tests/System.Runtime.Serialization.Primitives.Tests.csproj
index bef1cc634e6373..f5dfc930b8aae9 100644
--- a/src/libraries/System.Runtime.Serialization.Primitives/tests/System.Runtime.Serialization.Primitives.Tests.csproj
+++ b/src/libraries/System.Runtime.Serialization.Primitives/tests/System.Runtime.Serialization.Primitives.Tests.csproj
@@ -15,6 +15,6 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 </Project>
\ No newline at end of file
diff --git a/src/libraries/System.Runtime/tests/System.Resources.ResourceManager.Tests/System.Resources.ResourceManager.Tests.csproj b/src/libraries/System.Runtime/tests/System.Resources.ResourceManager.Tests/System.Resources.ResourceManager.Tests.csproj
index 092cefcb32d7ce..32f70b024ae36d 100644
--- a/src/libraries/System.Runtime/tests/System.Resources.ResourceManager.Tests/System.Resources.ResourceManager.Tests.csproj
+++ b/src/libraries/System.Runtime/tests/System.Resources.ResourceManager.Tests/System.Resources.ResourceManager.Tests.csproj
@@ -66,7 +66,7 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
   <!--
     MSBuild on .NET Core doesn't support non-string resources. See https://github.com/Microsoft/msbuild/issues/2221
diff --git a/src/libraries/System.Runtime/tests/System.Runtime.Tests/System.Runtime.Tests.csproj b/src/libraries/System.Runtime/tests/System.Runtime.Tests/System.Runtime.Tests.csproj
index e62c619d9c1bf9..8d89746c86d76b 100644
--- a/src/libraries/System.Runtime/tests/System.Runtime.Tests/System.Runtime.Tests.csproj
+++ b/src/libraries/System.Runtime/tests/System.Runtime.Tests/System.Runtime.Tests.csproj
@@ -387,7 +387,7 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
   <Import Project="$(CommonTestPath)ComplianceTests\GB18030\GB18030.Shared.projitems" />
 </Project>
diff --git a/src/libraries/System.Security.Cryptography/tests/System.Security.Cryptography.Tests.csproj b/src/libraries/System.Security.Cryptography/tests/System.Security.Cryptography.Tests.csproj
index 0111b5943403bc..633a3c02cb5cc3 100644
--- a/src/libraries/System.Security.Cryptography/tests/System.Security.Cryptography.Tests.csproj
+++ b/src/libraries/System.Security.Cryptography/tests/System.Security.Cryptography.Tests.csproj
@@ -943,6 +943,6 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 </Project>
diff --git a/src/libraries/System.Text.RegularExpressions/tests/FunctionalTests/System.Text.RegularExpressions.Tests.csproj b/src/libraries/System.Text.RegularExpressions/tests/FunctionalTests/System.Text.RegularExpressions.Tests.csproj
index d4e2839cbdfede..ca82a7c728d6d0 100644
--- a/src/libraries/System.Text.RegularExpressions/tests/FunctionalTests/System.Text.RegularExpressions.Tests.csproj
+++ b/src/libraries/System.Text.RegularExpressions/tests/FunctionalTests/System.Text.RegularExpressions.Tests.csproj
@@ -96,7 +96,7 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 
   <ItemGroup>
diff --git a/src/libraries/System.Threading.Channels/tests/System.Threading.Channels.Tests.csproj b/src/libraries/System.Threading.Channels/tests/System.Threading.Channels.Tests.csproj
index 0c3258e6c0a1b6..86380ac8ab2e2a 100644
--- a/src/libraries/System.Threading.Channels/tests/System.Threading.Channels.Tests.csproj
+++ b/src/libraries/System.Threading.Channels/tests/System.Threading.Channels.Tests.csproj
@@ -28,7 +28,7 @@
     <!-- Reference the `NetCoreAppMinimum` build which has a functional BinaryFormatter and force a private copy to ensure it's not excluded -->
     <ProjectReference Include="$(LibrariesProjectRoot)System.Runtime.Serialization.Formatters\src\System.Runtime.Serialization.Formatters.csproj"
                       Private="true"
-                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" />
+                      SetTargetFramework="TargetFramework=$(NetCoreAppMinimum)" Condition="'$(TargetOS)' != 'browser' and '$(TargetOS)' != 'wasi'" />
   </ItemGroup>
 
   <ItemGroup Condition="'$(TargetFrameworkIdentifier)' == '.NETFramework'">