diff --git a/recipes/molecule-signature/meta.yaml b/recipes/molecule-signature/meta.yaml
new file mode 100644
index 0000000000000..5c6ca4a2c270d
--- /dev/null
+++ b/recipes/molecule-signature/meta.yaml
@@ -0,0 +1,53 @@
+{% set package = "molecule-signature" %}
+{% set version = "2.0.1" %}
+{% set python_min = "3.10" %}
+
+package:
+  name: {{ package|lower }}
+  version: {{ version }}
+
+source:
+  url: https://github.com/brsynth/molecule-signature/archive/refs/tags/{{ version }}.tar.gz
+  sha256: 252bd29e8e58a0abbdc112475cbc0092e9596ad1bc9c3a304fb03d15f7e04d80
+
+build:
+  number: 0
+  noarch: python
+  script: {{ PYTHON }} -m pip install . -vv --no-deps --no-build-isolation
+
+
+requirements:
+  host:
+    - python {{ python_min }}
+    - pip
+    - setuptools
+  run:
+    - python >={{ python_min }}
+    - networkx
+    - numpy
+    - pandas
+    - python
+    - rdkit
+    - scipy
+    - sympy
+
+test:
+  source_files:
+    - tests
+  imports:
+    - molsig
+  requires:
+    - python {{ python_min }}
+    - pytest
+  commands:
+    - python -m pytest
+
+about:
+  home: https://github.com/brsynth/molecule-signature
+  summary: Signature-based enumeration of molecules from morgan fingerprints
+  license: MIT
+  license_file: LICENSE.md
+
+extra:
+  recipe-maintainers:
+    - tduigou