diff --git a/biolink-model.yaml b/biolink-model.yaml
index 2f102eb4f..474524d9d 100644
--- a/biolink-model.yaml
+++ b/biolink-model.yaml
@@ -11859,6 +11859,10 @@ enums:
         is_a: transport
       splicing:
       molecular_interaction:
+      guanyl_nucleotide_exchange:
+        is_a: molecular_interaction
+      adenyl_nucleotide_exchange:
+        is_a: molecular_interaction
       molecular_modification:
       acetylation:
         is_a: molecular_modification