diff --git a/.github/workflows/requirements.txt b/.github/workflows/requirements.txt
index 915b278..a0ca7da 100644
--- a/.github/workflows/requirements.txt
+++ b/.github/workflows/requirements.txt
@@ -1,4 +1,5 @@
 cython ~=3.0
 wheel
 auditwheel <5.2
-setuptools >=46.4.0
+meson-python
+ninja
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 5bb4383..4c4bbd3 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -67,7 +67,7 @@ jobs:
     - name: Install test requirements
       run: python -m pip install -r pyrodigal/tests/requirements.txt
     - name: Build C extension in debug mode
-      run: python setup.py build_ext --inplace --debug
+      run: python -m pip install --no-build-isolation --editable .
     - name: Test without coverage
       run: python -m unittest discover -vv
 
@@ -130,7 +130,7 @@ jobs:
     - name: Install test requirements
       run: python -m pip install -r pyrodigal/tests/requirements.txt
     - name: Build C extension in debug mode
-      run: python setup.py build_ext --inplace --debug --plat-name macos-x86_64
+      run: python -m pip install --no-build-isolation --editable .
     - name: Test without coverage
       run: python -m unittest discover -vv
 
@@ -193,7 +193,7 @@ jobs:
     - name: Install test requirements
       run: python -m pip install -r pyrodigal/tests/requirements.txt
     - name: Build C extension
-      run: python setup.py build_ext --inplace
+      run: python -m pip install --no-build-isolation --editable .
     - name: Test without coverage
       run: python -m unittest discover -vv
 
@@ -230,7 +230,7 @@ jobs:
     - name: Build Prodigal with optimizations
       run: python setup.py build_clib
     - name: Build Cython extension in debug mode
-      run: python setup.py build_ext --inplace --debug
+      run: python -m pip install --no-build-isolation --editable . --config-settings setup-args="-Dbuildtype=debug"
     - name: Test with coverage
       run: python -m coverage run -m unittest discover -vv
     - name: Report coverage