diff --git a/.github/workflows/e2e-cache-freethreaded.yml b/.github/workflows/e2e-cache-freethreaded.yml
index 97cc44bcf..2c28be524 100644
--- a/.github/workflows/e2e-cache-freethreaded.yml
+++ b/.github/workflows/e2e-cache-freethreaded.yml
@@ -219,3 +219,56 @@ jobs:
           pip-version: '25.0.1'
       - name: Install dependencies
         run: pip install numpy pandas requests
+
+  python-pip-dependencies-caching-with-pip-install:
+    name: Test pip (Python ${{ matrix.python-version}}, ${{ matrix.os }})
+    runs-on: ${{ matrix.os }}
+    strategy:
+      fail-fast: false
+      matrix:
+        os:
+          [
+            ubuntu-latest,
+            ubuntu-22.04,
+            ubuntu-24.04-arm,
+            ubuntu-22.04-arm,
+            windows-latest,
+            macos-latest,
+            macos-13
+          ]
+        python-version: [3.13.0t, 3.13.1t, 3.13.2t]
+    steps:
+      - uses: actions/checkout@v5
+      - name: Setup Python
+        uses: ./
+        with:
+          python-version: ${{ matrix.python-version }}
+          cache: 'pip'
+          pip-install: numpy pandas requests
+
+  python-pip-dependencies-caching-path-with-pip-install:
+    name: Test pip (Python ${{ matrix.python-version}}, ${{ matrix.os }}, caching path)
+    runs-on: ${{ matrix.os }}
+    strategy:
+      fail-fast: false
+      matrix:
+        os:
+          [
+            ubuntu-latest,
+            ubuntu-22.04,
+            ubuntu-24.04-arm,
+            ubuntu-22.04-arm,
+            windows-latest,
+            macos-latest,
+            macos-13
+          ]
+        python-version: [3.13.0t, 3.13.1t, 3.13.2t]
+    steps:
+      - uses: actions/checkout@v5
+      - name: Setup Python
+        uses: ./
+        with:
+          python-version: ${{ matrix.python-version }}
+          cache: 'pip'
+          cache-dependency-path: __tests__/data/requirements.txt
+          pip-install: numpy pandas requests
diff --git a/.github/workflows/e2e-cache.yml b/.github/workflows/e2e-cache.yml
index c073e2538..363139a03 100644
--- a/.github/workflows/e2e-cache.yml
+++ b/.github/workflows/e2e-cache.yml
@@ -311,3 +311,56 @@ jobs:
           pip-version: '25.0.1'
       - name: Install dependencies
         run: pip install numpy pandas requests
+
+  python-pip-dependencies-caching-with-pip-install:
+    name: Test pip (Python ${{ matrix.python-version}}, ${{ matrix.os }})
+    runs-on: ${{ matrix.os }}
+    strategy:
+      fail-fast: false
+      matrix:
+        os:
+          [
+            ubuntu-latest,
+            ubuntu-24.04-arm,
+            ubuntu-22.04,
+            ubuntu-22.04-arm,
+            windows-latest,
+            macos-latest,
+            macos-13
+          ]
+        python-version: ['3.9', '3.10', '3.11', '3.12', '3.13']
+    steps:
+      - uses: actions/checkout@v5
+      - name: Setup Python
+        uses: ./
+        with:
+          python-version: ${{ matrix.python-version }}
+          cache: 'pip'
+          pip-install: numpy pandas requests
+
+  python-pip-dependencies-caching-path-with-pip-install:
+    name: Test pip (Python ${{ matrix.python-version}}, ${{ matrix.os }}, caching path)
+    runs-on: ${{ matrix.os }}
+    strategy:
+      fail-fast: false
+      matrix:
+        os:
+          [
+            ubuntu-latest,
+            ubuntu-24.04-arm,
+            ubuntu-22.04,
+            ubuntu-22.04-arm,
+            windows-latest,
+            macos-latest,
+            macos-13
+          ]
+        python-version: ['3.9', '3.10', '3.11', '3.12', '3.13']
+    steps:
+      - uses: actions/checkout@v5
+      - name: Setup Python
+        uses: ./
+        with:
+          python-version: ${{ matrix.python-version }}
+          cache: 'pip'
+          cache-dependency-path: __tests__/data/requirements.txt
+          pip-install: numpy pandas requests
diff --git a/README.md b/README.md
index cb53f2569..a6fb5bc5d 100644
--- a/README.md
+++ b/README.md
@@ -118,6 +118,7 @@ See examples of using `cache` and `cache-dependency-path` for `pipenv` and `poet
 - [Using `setup-python` on GHES](docs/advanced-usage.md#using-setup-python-on-ghes)
 - [Allow pre-releases](docs/advanced-usage.md#allow-pre-releases)
 - [Using the pip-version input](docs/advanced-usage.md#using-the-pip-version-input)
+- [Using the pip-install input](docs/advanced-usage.md#using-the-pip-install-input)
 
 ## Recommended permissions
 
diff --git a/action.yml b/action.yml
index df6c8235b..7a9a7b634 100644
--- a/action.yml
+++ b/action.yml
@@ -31,6 +31,8 @@ inputs:
     default: false
   pip-version:
     description: "Used to specify the version of pip to install with the Python. Supported format: major[.minor][.patch]."
+  pip-install:
+    description: "Used to specify the packages to install with pip after setting up Python. Can be a requirements file or package names."
 outputs:
   python-version:
     description: "The installed Python or PyPy version. Useful when given a version range as input."
diff --git a/dist/setup/index.js b/dist/setup/index.js
index ba888f22f..6cd801411 100644
--- a/dist/setup/index.js
+++ b/dist/setup/index.js
@@ -97944,12 +97944,26 @@ const os = __importStar(__nccwpck_require__(857));
 const fs_1 = __importDefault(__nccwpck_require__(9896));
 const cache_factory_1 = __nccwpck_require__(665);
 const utils_1 = __nccwpck_require__(1798);
+const exec_1 = __nccwpck_require__(5236);
 function isPyPyVersion(versionSpec) {
     return versionSpec.startsWith('pypy');
 }
 function isGraalPyVersion(versionSpec) {
     return versionSpec.startsWith('graalpy');
 }
+function installPipPackages(pipInstall) {
+    return __awaiter(this, void 0, void 0, function* () {
+        core.info(`Installing pip packages: ${pipInstall}`);
+        try {
+            const installArgs = pipInstall.trim().split(/\s+/);
+            yield (0, exec_1.exec)('python', ['-m', 'pip', 'install', ...installArgs]);
+            core.info('Successfully installed pip packages');
+        }
+        catch (error) {
+            core.setFailed(`Failed to install pip packages from "${pipInstall}". Please verify that the package names, versions, or requirements files provided are correct and installable, that the specified packages and versions can be resolved from PyPI or the configured package index, and that your network connection is stable and allows access to the package index.`);
+        }
+    });
+}
 function cacheDependencies(cache, pythonVersion) {
     return __awaiter(this, void 0, void 0, function* () {
         const cacheDependencyPath = core.getInput('cache-dependency-path') || undefined;
@@ -98038,6 +98052,10 @@ function run() {
                 if (cache && (0, utils_1.isCacheFeatureAvailable)()) {
                     yield cacheDependencies(cache, pythonVersion);
                 }
+                const pipInstall = core.getInput('pip-install');
+                if (pipInstall) {
+                    yield installPipPackages(pipInstall);
+                }
             }
             else {
                 core.warning('The `python-version` input is not set.  The version of Python currently in `PATH` will be used.');
diff --git a/docs/advanced-usage.md b/docs/advanced-usage.md
index 55b41d54f..e20eb0582 100644
--- a/docs/advanced-usage.md
+++ b/docs/advanced-usage.md
@@ -23,6 +23,7 @@
 - [Using `setup-python` on GHES](advanced-usage.md#using-setup-python-on-ghes)
 - [Allow pre-releases](advanced-usage.md#allow-pre-releases)
 - [Using the pip-version input](advanced-usage.md#using-the-pip-version-input)
+- [Using the pip-install input](advanced-usage.md#using-the-pip-install-input)
 
 ## Using the `python-version` input
 
@@ -672,3 +673,20 @@ The version of Pip should be specified in the format `major`, `major.minor`, or
 > The `pip-version` input is supported only with standard Python versions. It is not available when using PyPy or GraalPy.
 
 > Using a specific or outdated version of pip may result in compatibility or security issues and can cause job failures. For best practices and guidance, refer to the official [pip documentation](https://pip.pypa.io/en/stable/).
+
+## Using the pip-install input
+
+The `pip-install` input allows you to install dependencies as part of the Python setup step.
+
+
+```yaml
+      steps:
+      - uses: actions/checkout@v5
+      - name: Set up Python
+        uses: actions/setup-python@v6
+        with:
+          python-version: '3.13'
+          pip-install: -r requirements.txt
+```
+> Note: This feature is intended for standard pip-based dependency installations.
+For complex workflows, or alternative package managers (e.g., poetry, pipenv), we recommend using separate steps to maintain clarity and flexibility.
diff --git a/src/setup-python.ts b/src/setup-python.ts
index 5d585d734..91a0c1761 100644
--- a/src/setup-python.ts
+++ b/src/setup-python.ts
@@ -13,6 +13,7 @@ import {
   getVersionInputFromFile,
   getVersionsInputFromPlainFile
 } from './utils';
+import {exec} from '@actions/exec';
 
 function isPyPyVersion(versionSpec: string) {
   return versionSpec.startsWith('pypy');
@@ -22,6 +23,19 @@ function isGraalPyVersion(versionSpec: string) {
   return versionSpec.startsWith('graalpy');
 }
 
+async function installPipPackages(pipInstall: string) {
+  core.info(`Installing pip packages: ${pipInstall}`);
+  try {
+    const installArgs = pipInstall.trim().split(/\s+/);
+    await exec('python', ['-m', 'pip', 'install', ...installArgs]);
+    core.info('Successfully installed pip packages');
+  } catch (error) {
+    core.setFailed(
+      `Failed to install pip packages from "${pipInstall}". Please verify that the package names, versions, or requirements files provided are correct and installable, that the specified packages and versions can be resolved from PyPI or the configured package index, and that your network connection is stable and allows access to the package index.`
+    );
+  }
+}
+
 async function cacheDependencies(cache: string, pythonVersion: string) {
   const cacheDependencyPath =
     core.getInput('cache-dependency-path') || undefined;
@@ -145,6 +159,10 @@ async function run() {
       if (cache && isCacheFeatureAvailable()) {
         await cacheDependencies(cache, pythonVersion);
       }
+      const pipInstall = core.getInput('pip-install');
+      if (pipInstall) {
+        await installPipPackages(pipInstall);
+      }
     } else {
       core.warning(
         'The `python-version` input is not set.  The version of Python currently in `PATH` will be used.'