diff --git a/test/e2e/specs/editor/various/cross-origin-isolation.spec.js b/test/e2e/specs/editor/various/cross-origin-isolation.spec.js
index 77480feedccdc1..93baca114212ad 100644
--- a/test/e2e/specs/editor/various/cross-origin-isolation.spec.js
+++ b/test/e2e/specs/editor/various/cross-origin-isolation.spec.js
@@ -35,7 +35,10 @@ test.use( {
 	},
 } );
 
-test.describe( 'Cross-origin isolation', () => {
+// Client-side media processing (and cross-origin isolation) is temporarily
+// disabled in the Gutenberg plugin. Skip until re-enabled.
+// See https://github.com/WordPress/gutenberg/pull/75756
+test.describe.skip( 'Cross-origin isolation', () => {
 	test.beforeEach( async ( { admin } ) => {
 		await admin.createNewPost();
 	} );