diff --git a/packages/e2e-tests/plugins/enable-client-side-media-processing.php b/packages/e2e-tests/plugins/enable-client-side-media-processing.php
new file mode 100644
index 00000000000000..32105dbdbaa4c2
--- /dev/null
+++ b/packages/e2e-tests/plugins/enable-client-side-media-processing.php
@@ -0,0 +1,10 @@
+<?php
+/**
+ * Plugin Name: Gutenberg Test Plugin: Enable Client-Side Media Processing
+ * Plugin URI: https://github.com/WordPress/gutenberg
+ * Author: Gutenberg Team
+ *
+ * @package gutenberg-test-enable-client-side-media-processing
+ */
+
+add_filter( 'wp_client_side_media_processing_enabled', '__return_true' );
diff --git a/test/e2e/specs/editor/various/cross-origin-isolation.spec.js b/test/e2e/specs/editor/various/cross-origin-isolation.spec.js
index 77480feedccdc1..cb5e426257bc43 100644
--- a/test/e2e/specs/editor/various/cross-origin-isolation.spec.js
+++ b/test/e2e/specs/editor/various/cross-origin-isolation.spec.js
@@ -36,13 +36,30 @@ test.use( {
 } );
 
 test.describe( 'Cross-origin isolation', () => {
+	test.beforeAll( async ( { requestUtils } ) => {
+		// Client-side media processing (and cross-origin isolation) is
+		// temporarily disabled in the Gutenberg plugin.
+		// See https://github.com/WordPress/gutenberg/pull/75756
+		await requestUtils.activatePlugin(
+			'gutenberg-test-plugin-enable-client-side-media-processing'
+		);
+	} );
+
+	test.afterAll( async ( { requestUtils } ) => {
+		await requestUtils.deactivatePlugin(
+			'gutenberg-test-plugin-enable-client-side-media-processing'
+		);
+	} );
+
 	test.beforeEach( async ( { admin } ) => {
 		await admin.createNewPost();
 	} );
 
-	test( 'should be cross-origin isolated by default', async ( { page } ) => {
-		// Verify that cross-origin isolation IS enabled (default state
-		// now that client-side media processing is graduated).
+	test( 'should be cross-origin isolated when client-side media processing is enabled', async ( {
+		page,
+	} ) => {
+		// Verify that cross-origin isolation IS enabled when
+		// client-side media processing is active.
 		const isCrossOriginIsolated = await page.evaluate(
 			() => window.crossOriginIsolated
 		);