diff --git a/Dockerfile b/Dockerfile
new file mode 100644
index 0000000..6943901
--- /dev/null
+++ b/Dockerfile
@@ -0,0 +1,22 @@
+FROM python:2.7.18
+
+# Donwnload and install RNA
+RUN wget https://rna.urmc.rochester.edu/Releases/current/RNAstructureLinuxTextInterfaces64bit.tgz
+RUN tar -zxvf RNAstructureLinuxTextInterfaces64bit.tgz
+RUN cd RNAstructure && \
+    make all
+
+ENV PATH=$PATH:/RNAstructure/exe
+ENV DATAPATH=/RNAstructure/data_tables
+
+# Setup Metaplotlib
+RUN python -m pip install -U pip setuptools
+RUN python -m pip install matplotlib
+
+# Setup httplib2
+RUN pip install httplib2
+
+# Copy required files
+RUN mkdir /Superfold
+WORKDIR Superfold
+COPY . /Superfold/
diff --git a/README b/README
index d9effe8..2e52b74 100644
--- a/README
+++ b/README
@@ -3,6 +3,18 @@ Superfold installation, execution, and troubleshooting.
 Gregg Rice 2014
 gmr@unc.edu
 
+###################################################################################
+Docker build
+===================================================================================
+to build run:
+    docker build . -t superfold
+
+to run:
+    mkdir data
+    docker run -it -v ./data:/Superfold/data superfold /bin/bash
+
+The data directory will be "sheared" between your container and local system
+
 ###################################################################################
 Requirements: