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Users have noted difficulty in running Superfold on macs locally. Specifically, they have run into issues with the path assignments for RNA Structure programs. For example, Fold commands in Superfold will call the default unix command fold, rather than the RNA structure program.
We will work on addressing this problem in the next update.
For now we would recommend either A) run Superfold on a linux/Unix system or B) replace all RNA Structure command calls with their absolute path in your file architecture ie. Fold would become /usr/Admin/Documents/RNAStructure/exe/Fold and so on.
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