file size are double as registration

[josenimo]

Hey @kbestak,

I am sure you are busy enough, however this is becoming an issue for our groups in Berlin, since my mcmicro runs are being very bloated because of backsub.
If you have any ideas on how to compress these bad boys, that would be amazing.

Perhaps, consider downscaling to 8bit? Not sure

[josenimo]

Hello friends,

I am happy to see improvements on backsub :)
is there a timeline for next release, do you need beta testing?
I am here because the size issue is killing us a little haha, we have a dataset of 7 cycles, where the raw data is about 150gb (compressed czi), and the resulting backsub stack is 450gb 🙃

[kbestak]

Hey Jose! We're working on this fast, my feeling is we'll have the release ready during next week. Thanks for offering help with testing, I'll reach out if needed. Just for your info, we're adding LZW compression now to mitigate the issues you're observing.

[kbestak]

Hey @josenimo , we just made the 0.5.1 release here that supports lzw or zlib compression. PRs to nf-core and legacy MCMICRO will be coming soon.

I'll close this issue now as we've addressed it, but please reach out if you find any unexpected behaviours.