diff --git a/monai/networks/nets/__init__.py b/monai/networks/nets/__init__.py
index c1917e5293..0d02f95efa 100644
--- a/monai/networks/nets/__init__.py
+++ b/monai/networks/nets/__init__.py
@@ -144,3 +144,4 @@
 from .vnet import VNet
 from .voxelmorph import VoxelMorph, VoxelMorphUNet
 from .vqvae import VQVAE
+from .u_mamba import UMambaUNet
diff --git a/monai/networks/nets/u_mamba.py b/monai/networks/nets/u_mamba.py
new file mode 100644
index 0000000000..4697ad4a66
--- /dev/null
+++ b/monai/networks/nets/u_mamba.py
@@ -0,0 +1,110 @@
+# Copyright (c) MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import torch
+import torch.nn as nn
+import torch.nn.functional as F
+
+# Simple placeholder for the SSM (Mamba-like block)
+class SSMBlock(nn.Module):
+    def __init__(self, dim):
+        super().__init__()
+        self.linear1 = nn.Linear(dim, dim)
+        self.linear2 = nn.Linear(dim, dim)
+
+    def forward(self, x):
+        # x: (B, L, C)
+        return self.linear2(torch.silu(self.linear1(x)))
+
+class UMambaBlock(nn.Module):
+    def __init__(self, in_channels, hidden_channels):
+        super().__init__()
+        self.conv_res1 = nn.Sequential(
+            nn.Conv3d(in_channels, in_channels, kernel_size=3, padding=1),
+            nn.InstanceNorm3d(in_channels),
+            nn.LeakyReLU(),
+        )
+        self.conv_res2 = nn.Sequential(
+            nn.Conv3d(in_channels, in_channels, kernel_size=3, padding=1),
+            nn.InstanceNorm3d(in_channels),
+            nn.LeakyReLU(),
+        )
+
+        self.layernorm = nn.LayerNorm(hidden_channels)
+        self.linear1 = nn.Linear(in_channels, hidden_channels)
+        self.linear2 = nn.Linear(hidden_channels, in_channels)
+        self.conv1d = nn.Conv1d(hidden_channels, hidden_channels, kernel_size=3, padding=1)
+        self.ssm = SSMBlock(hidden_channels)
+
+    def forward(self, x):
+        # x: (B, C, H, W, D)
+        residual = x
+        x = self.conv_res1(x)
+        x = self.conv_res2(x) + residual
+
+        B, C, H, W, D = x.shape
+        x_flat = x.view(B, C, -1).permute(0, 2, 1)  # (B, L, C)
+        x_norm = self.layernorm(x_flat)
+        x_proj = self.linear1(x_norm)
+
+        x_silu = torch.silu(x_proj)
+        x_ssm = self.ssm(x_silu)
+        x_conv1d = self.conv1d(x_proj.permute(0, 2, 1)).permute(0, 2, 1)
+
+        x_combined = torch.silu(x_conv1d) * torch.silu(x_ssm)
+        x_out = self.linear2(x_combined)
+        x_out = x_out.permute(0, 2, 1).view(B, C, H, W, D)
+
+        return x + x_out  # Residual connection
+
+class ResidualBlock(nn.Module):
+    def __init__(self, channels):
+        super().__init__()
+        self.block = nn.Sequential(
+            nn.Conv3d(channels, channels, kernel_size=3, padding=1),
+            nn.BatchNorm3d(channels),
+            nn.ReLU(),
+            nn.Conv3d(channels, channels, kernel_size=3, padding=1),
+            nn.BatchNorm3d(channels),
+        )
+
+    def forward(self, x):
+        return F.relu(x + self.block(x))
+
+class UMambaUNet(nn.Module):
+    def __init__(self, in_channels=1, out_channels=1, base_channels=32):
+        super().__init__()
+        self.enc1 = UMambaBlock(in_channels, base_channels)
+        self.down1 = nn.Conv3d(base_channels, base_channels*2, kernel_size=3, stride=2, padding=1)
+
+        self.enc2 = UMambaBlock(base_channels*2, base_channels*2)
+        self.down2 = nn.Conv3d(base_channels*2, base_channels*4, kernel_size=3, stride=2, padding=1)
+
+        self.bottleneck = UMambaBlock(base_channels*4, base_channels*4)
+
+        self.up2 = nn.ConvTranspose3d(base_channels*4, base_channels*2, kernel_size=2, stride=2)
+        self.dec2 = ResidualBlock(base_channels*4)
+
+        self.up1 = nn.ConvTranspose3d(base_channels*2, base_channels, kernel_size=2, stride=2)
+        self.dec1 = ResidualBlock(base_channels*2)
+
+        self.final = nn.Conv3d(base_channels, out_channels, kernel_size=1)
+
+    def forward(self, x):
+        x1 = self.enc1(x)
+        x2 = self.enc2(self.down1(x1))
+        x3 = self.bottleneck(self.down2(x2))
+
+        x = self.up2(x3)
+        x = self.dec2(torch.cat([x, x2], dim=1))
+        x = self.up1(x)
+        x = self.dec1(torch.cat([x, x1], dim=1))
+        return self.final(x)
diff --git a/tests/test_networks_u_mamba.py b/tests/test_networks_u_mamba.py
new file mode 100644
index 0000000000..02f75226da
--- /dev/null
+++ b/tests/test_networks_u_mamba.py
@@ -0,0 +1,22 @@
+import unittest
+import torch
+from monai.networks.nets import UMambaUNet
+
+class TestUMamba(unittest.TestCase):
+    def test_forward_shape(self):
+        # Set up input dimensions and model
+        input_tensor = torch.randn(2, 1, 16, 64, 64)
+        model = UMambaUNet(in_channels=1, out_channels=2)
+        output = model(input_tensor)
+        self.assertEqual(output.shape, (2, 2, 16, 64, 64))
+
+    def test_script(self):
+        # Test JIT scripting if supported
+        model = UMambaUNet(in_channels=1, out_channels=2)
+        scripted = torch.jit.script(model)
+        x = torch.randn(1, 1, 64, 64)
+        out = scripted(x)
+        self.assertEqual(out.shape, (1, 2, 64, 64))
+
+if __name__ == "__main__":
+    unittest.main()