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docs: add NOMINATION_REPORT.md — full methodology behind 89 AMP nominees
Complete scientific documentation of how the 89 Phase 3 candidates were
found, scored, filtered, and selected. Suitable for sharing with expert
reviewers and as a pre-publication methods record.
Sections:
1. Abstract (89 nominees, computational only, no bio claims)
2. Motivation (cationic AMPs, why short variants, why this approach)
3. Seed templates (5 seeds, family rationale, published sources)
4. Candidate generation (3 strategies, conservative groups, rng_seed=2024, 383 total)
5. Scoring pipeline (6 dimensions with formulas and references)
- Activity-likeness (Scorer 1: heuristic)
- Boman activity (Scorer 2: Boman 2003 potentials, independent)
- Model disagreement (|act - boman| uncertainty proxy)
- Safety proxy (hemolysis risk flags)
- Synthesis feasibility
- Novelty (Levenshtein vs 45 curated references)
- Ensemble (pre-registered weights)
6. Selection criteria (hard filters + ranking + greedy diversity)
7. Results
- 89 selected from 383 (pass-rate 23%)
- Per-seed breakdown: SEED-003 best Boman (0.538), SEED-005 best ensemble (0.863)
- Novelty distribution: 9 high, 58 mid, 22 low
- Top-10 table with dual-scorer columns
- Suggested 5-candidate pilot (Boman × low-disagreement criterion)
8. Evidence trail (all artifacts with locations)
9. Reproducibility (make phase3 from clean checkout)
10. What we do not know (mandatory integrity section)
11. Safety and dual-use assessment
12. Next steps (human gates only)
13. References (Boman 2003, Eisenberg 1984, Kyte-Doolittle 1982, Zasloff 1987...)1 parent 14d43d0 commit 653d527
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