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RESPONSIBLE_USE.md

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Responsible Use

Purpose

This policy defines allowed and disallowed use of OpenAMP Foundry.

OpenAMP is an open dry-lab infrastructure project for antimicrobial peptide candidate triage, evidence packaging, benchmark governance, and qualified review.

It is not a clinical, laboratory-instruction, or unrestricted biological-design system.

Allowed uses

You may use this project to:

  • evaluate peptide candidates computationally;
  • build reproducible benchmarks;
  • generate auditable evidence certificates;
  • compare scorers against cheap baselines;
  • document model limitations;
  • prepare candidates for qualified expert review;
  • produce external review packets;
  • pre-register candidate-selection logic;
  • ingest structured result summaries at a safe abstraction level;
  • preserve safe negative and positive scientific findings;
  • build validators, schemas, reports, and tooling that improve auditability.

Disallowed uses

You may not use this project to:

  • design or optimize harmful biological capabilities;
  • optimize toxicity, unsafe delivery, persistence, immune evasion, or pathogenicity;
  • bypass safety review;
  • bypass qualified expert review;
  • publish unscreened high-risk candidate lists;
  • claim biological activity without qualified evidence;
  • claim human safety from dry-lab scores;
  • market candidates as treatments;
  • use outputs as medical or clinical advice;
  • provide operational laboratory instructions through this repo;
  • misrepresent computational nomination as biological validation.

Claim rules

Allowed before experimental evidence:

  • computationally nominated candidate;
  • dry-lab candidate;
  • selected for expert review;
  • selected by reproducible pipeline;
  • evidence package;
  • candidate-selection hypothesis.

Not allowed before sufficient evidence:

  • active antimicrobial;
  • safe;
  • drug candidate;
  • therapeutic;
  • clinically useful;
  • proven;
  • AI-discovered antibiotic.

Use docs/evidence/PROOF_LADDER.md and docs/evidence/CLAIM_REVIEW_CHECKLIST.md.

Data and artifact rules

Users must respect:

  • third-party data licenses;
  • dataset redistribution limits;
  • citation requirements;
  • model release boundaries;
  • candidate release review;
  • safety review decisions;
  • institutional and legal requirements.

If release status is unclear, do not publish the artifact.

Agent use

AI agents may work on this repo only within explicit safety and task boundaries.

Good agent work:

  • tests;
  • validators;
  • doc consistency;
  • benchmark scaffolding;
  • schema examples;
  • report improvements;
  • reproducibility checks;
  • safe onboarding improvements.

Agents must not autonomously strengthen claims, release candidates, change safety policy, change model release policy, or add external-facing biological instructions.

External partner use

External partners should treat OpenAMP outputs as computational evidence packages, not as instructions.

Any experimental, institutional, or clinical decision remains outside this repository and requires qualified oversight.

Enforcement

Maintainers may reject, edit, restrict, remove, or revert contributions that violate this policy.

For sensitive issues, use safety-review workflows rather than public artifact release.

Final note

This document is a governance policy, not a substitute for law, institutional review, biosafety review, ethics review, or domain expert review.