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---
layout: page
title: Research
permalink: /research/
---
<div class="home">
<h2>Improving Heat Tolerance in Cowpea</h2>
<img src="{{ site.github_url }}{{ site.images_dir }}cowpea_accessions.jpg" style="height: 500px;"><br>
Figure depicting cowpea accessions relative to temperature gradients across Africa. Figure courtesy of Kevin Volz.<br>
<h4 style="font-size:150%;">Unraveling the genetics of cowpea adaptation to high temperatures for legume improvement</h4>
Funded by the <a href="https://foundationfar.org" rel="external">The Foundation for Food and Agriculture Research</a> grant <a href="https://foundationfar.org/news/ffar-grants-develop-heat-tolerance-in-crops/" rel="external">ICRC20-0000000032</a>.<br>
PI is <a href="https://scholar.google.com/citations?user=5bJjvhUAAAAJ&hl=en" rel="external">María Muñoz-Amatriain</a> with coPIs <a href="http://smithlab.cfans.umn.edu/" rel="external">Esteban Rios</a>, <a href="https://africa.ufl.edu/people/faculty/emeritus-faculty/boote-2/" rel="external">Kenneth Boote</a>, and <a href="hhttps://www.iita.org/iita-staff/boukar-ousmane/" rel="external">Ousmane Boukar</a>.<br>
<br>
Liang Q, Muñoz-Amatriaín M, Shu S, Lo S, Wu X, Carlson JW, Davidson P, Goodstein DM, Phillips J, Janis NM, Lee EJ, Liang C, Morrell PL, Farmer AD, Xu P, Close TJ, Lonardi S (2023) A view of the pan-genome of domesticated Cowpea (Vigna unguiculata [L.] Walp.). Plant Genome e20319.<br>
• <a href="https://doi.org/10.1002/tpg2.20319" rel="external">Journal publication</a> • <a href="https://github.com/MorrellLAB/Cowpea_Pangenome" rel="external">GitHub</a><br>
<h2>The Role of Deleterious Mutations</h2>
<img src="{{ site.github_url }}{{ site.images_dir }}del_muts_F1.jpg" style="height: 200px;"><br>
Figure 1 from Kono et al. (2016). The Role of Deleterious Substitutions in Crop Genomes. MBE 33: 1669-1678<br>
<h4 style="font-size:150%;">Deleterious Mutations and the Response to Strong Selection in a Self-fertilizing Crop</h4>
Funded by the <a href="http://www.nsf.gov/" rel="external">National Science Foundation</a> grant <a href="https://www.nsf.gov/awardsearch/showAward?AWD_ID=1339393" rel="external">IOS-1339393</a>.<br>
Co-PIs are <a href="http://www.genetics.wustl.edu/jflab/" rel="external">Justin Fay</a> and <a href="http://smithlab.cfans.umn.edu/" rel="external">Kevin Smith</a>.<br>
<br>
Kono TJY, Liu C, Vonderharr EE, Koenig D, Fay JC, Smith KP, Morrell PL (2019). The fate of deleterious variants in a barley genomic prediction population. Genetics. <br>
• <a href="https://doi.org/10.1534/genetics.119.302733" rel="external">Journal publication</a> • <a href="https://morrelllab.github.io/datasets/index.html" rel="external">Dataset</a><br>
<br>
Lei L, Poets AM, Liu C, Wyant SR, Hoffman PJ, Carter CK, Trantow RM, Li X, Muehlbauer GJ, Katagiri F, Morrell PL (2019). Environmental association identifies candidates for tolerance to low temperature and drought. G3. <br>
• <a href="https://doi.org/10.1534/g3.119.400401" rel="external">Journal publication</a> • <a href="https://morrelllab.github.io/datasets/index.html" rel="external">Dataset</a><br>
<br>
Hemshrot A, Poets A, Tyagi P, Lei L, Carter C, Hirsch C, Li L, Brown-Guedira G, Morrell P, Muelbauer G, Smith K (in review). Development of a multi-parent population for genetic mapping and allele discovery in six-row barley. Genetics. <br>
<br>
Kono TJY, Lei L, Shih C, Hoffman PJ, Morrell PL, Fay JC (2018). Comparative genomics approaches accurately predict deleterious variants in plants. G3.<br>
• <a href="https://doi.org/10.1534/g3.118.200563" rel="external">Journal publication</a> • <a href="https://www.biorxiv.org/content/early/2017/02/27/112318" rel="external">Preprint version</a><br>
<br>
Moyers BT, Morrell PL, McKay JK (2017). Genetic cost of domestication and improvement. Journal of Heredity 109: 103-116.<br>
• <a href="https://academic.oup.com/jhered/article/doi/10.1093/jhered/esx069/4064635/Genetic-costs-of-domestication-and-improvement" rel="external">Journal publication</a> • <a href="http://biorxiv.org/content/early/2017/03/29/122093" rel="external">Preprint version</a><br>
<br>
Liu Q, Zhou Y, Morrell PL, Gaut BS (2017). Deleterious variants in Asian rice and the potential cost of domestication. Molecular Biology and Evolution 34: 908-924.<br>
• <a href="https://academic.oup.com/mbe/article-abstract/doi/10.1093/molbev/msw296/2897207/Deleterious-variants-in-Asian-rice-and-the?redirectedFrom=fulltext" rel="external">Journal publication</a> • <a href="http://biorxiv.org/content/early/2016/12/14/057224" rel="external">Preprint version</a> • <a href="https://morrelllab.github.io/datasets/index.html" rel="external">Dataset</a><br>
<br>
Durvasula A, Hoffman PJ, Kent TV, Liu C, Kono TJY, Morrell PL, Ross-Ibarra J (2016). ANGSD-wrapper: utilities for analyzing next generation sequencing data. Molecular Ecology Resources 16: 1449-1454.<br>
• <a href="http://onlinelibrary.wiley.com/doi/10.1111/1755-0998.12578/full" rel="external">Journal publication</a> • <a href="https://peerj.com/preprints/1472/" rel="external">Preprint version</a> • <a href="https://github.com/mojaveazure/angsd-wrapper" rel="external">ANGSD-wrapper Github</a><br>
<br>
Kono TJY, Fu F, Mohammadi M, Hoffman PJ, Liu C, Stupar RM, Smith KP, Tiffin P, Fay JC, Morrell PL (2016). The role of deleterious substitutions in crop genomes. Molecular Biology and Evolution 33: 1669-1678.<br>
• <a href="http://mbe.oxfordjournals.org/content/early/2016/06/23/molbev.msw102" rel="external">Journal publication</a> • <a href="http://biorxiv.org/content/early/2016/05/12/033175" rel="external">Preprint version</a> • <a href="https://github.com/MorrellLAB/BAD_Mutations" rel="external">BAD_Mutations Github</a> • <a href="https://morrelllab.github.io/datasets/index.html" rel="external">Dataset</a><br>
<br>
Gaut BS, Diez CM, Morrell PL (2015). Genomics and the contrasting dynamics of annual and perennial domestication. Trends in Genetics 31: 709-719.<br>
• <a href="http://www.cell.com/trends/genetics/abstract/S0168-9525(15)00188-2" rel="external">Journal publication</a>
<h2>Biotechnology Risks</h2>
<img src="{{ site.github_url }}{{ site.images_dir }}biotech.jpg" style="height: 200px;"><br>
<h4 style="font-size:150%;">Comparison of mutation rates in soybean following transformation, mutagenesis, tissue culture and conventional breeding</h4>
Funded by the <a href="https://nifa.usda.gov/funding-opportunity/biotechnology-risk-assessment-research-grants-program-brag" rel="external">Biotechnology Risk Assessment Research Grants Program (BRAG)</a>.<br>
Awards page. <a href="http://cris.nifa.usda.gov/cgi-bin/starfinder/0?path=fastlink1.txt&id=anon&pass=&search=R=68661&format=WEBFMT6NT" rel="external">[Link 1]</a> <a href="http://cris.nifa.usda.gov/cgi-bin/starfinder/0?path=fastlink1.txt&id=anon&pass=&search=R=68661&format=WEBLINK" rel="external">[Link 2]</a><br>
Co-Project Directors are <a href="http://parrottlab.uga.edu/parrottlab/" rel="external">Wayne Parrott</a>, <a href="http://www.caes.uga.edu/departments/crop-soil/people/faculty/scott-jackson.html" rel="external">Scott Jackson</a>, and <a href="http://stuparlab.cfans.umn.edu/" rel="external">Robert Stupar</a>.<br>
<br>
Kono TJY, Lei L, Shih C, Hoffman PJ, Morrell PL, Fay JC (2018). Comparative genomics approaches accurately predict deleterious variants in plants. G3.<br>
• <a href="https://doi.org/10.1534/g3.118.200563" rel="external">Journal publication</a> • <a href="https://www.biorxiv.org/content/early/2017/02/27/112318" rel="external">Preprint version</a><br>
<br>
Michno JM, Stupar RM (2018). The importance of genotype identity, genetic heterogeneity, and bioinformatic handling for properly assessing genomic variation in transgenic plants. BMC Biotechnology 18: 38.<br>
• <a href="https://bmcbiotechnol.biomedcentral.com/articles/10.1186/s12896-018-0447-9" rel="external">Journal publication</a><br>
<br>
Anderson JE, Michno JM, Kono TJY, Stec AO, Campbell BW, Curtin SJ, Stupar RM (2016). Genomic variation and DNA repair associated with soybean transgenesis: a comparison to cultivars and mutagenized plants. BMC Biotechnology 16: 41.<br>
• <a href="https://bmcbiotechnol.biomedcentral.com/articles/10.1186/s12896-016-0271-z" rel="external">Journal publication</a>
</div>
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